Introduction: Optical coherence tomography (OCT) is a non-invasive imaging technique routinely used to visualize and quantify the layers of the retina. Originally developed for retinal diseases and glaucoma, optical coherence tomography (OCT) allows direct visualization and measurement of the optic nerve head topography and of retinal nerve fibre layer (RNFL) thickness with micron-scale resolut...

BACKGROUND Diabetic retinopathy is a microvascular neurodegenerative disorder in diabetic patients. Peripapillary retinal nerve fiber layer changes have been described in patients with preclinical diabetic retinopathy, but study results have been inconsistent. OBJECTIVE To assess changes in peripapillary retinal nerve fiber layer thickness in diabetic patients with preclinical diabetic retino...

Aim of work To evaluate the effect of refractive status and axial length of the eye on retinal nerve fiber layer (RNFL) thickness. Method A t tal of 116 eyes 62 subjects were enroll d in the study. RNFL thickness was measured using TOPCON 3D OCT 2000. Results Hyperopic group, as compared to normal, did not show any significant thickening for average, superior, inferior, nasal, and temporal quad...

Amyotrophic lateral sclerosis (ALS) is characterized by neuro-ophthalmological abnormalities beyond disturbed oculomotor control such as decreased visual acuity and disturbed visual evoked potentials. Here we report retinal alterations in a cohort of 24 patients with clinically definite (n = 20) or probable (n = 4) ALS as compared to matched controls. High-resolution spectral domain optical coh...

OBJECTIVE To compare optical coherence tomography (OCT) measurements on the retinal nerve fiber layer (RNFL) of healthy controls and patients with longitudinally extensive transverse myelitis (LETM) without previous optic neuritis. METHOD Twenty-six eyes from 26 patients with LETM and 26 control eyes were subjected to automated perimetry and OCT for comparison of RNFL measurements. RESULTS ...

purpose: to determine peripapillary retinal nerve fiber layer (rnfl) thickness by three-dimensional optical coherence tomography (3d-oct) in a normal iranian population and to evaluate the concordance of these measurements with those obtained by the second generation of optical coherence tomography (oct ii). methods: in a cross-sectional observational study, 96 normal iranian subjects 20-53 yea...

BACKGROUND Neuromyelitis optica (NMO) and relapsing-remitting multiple sclerosis (RRMS) are difficult to differentiate solely on clinical grounds. Optical coherence tomography (OCT) studies investigating retinal changes in both diseases focused primarily on the retinal nerve fiber layer (RNFL) while rare data are available on deeper intra-retinal layers. OBJECTIVE To detect different patterns...

Vigabatrin is an effective antiepileptic drug (AED) typically used in the treatment of refractory partial seizures and infantile spasms. Its use, however, is limited due to the concern of retinal toxicity and subsequent visual field defects. Herewith in we describe a case of vigabatrin toxicity that illustrates electroretinographic (ERG) changes occur before imaging and visual field deteriorati...

We evaluate a cohort of optic neuritis and neuromyelitis optica (NMO) spectrum disorders patients in a territory hospital in China. The peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC) were measured using spectral-domain OCT after 6 months of acute onset. The results showed that both the peripapillary RNFL and macular GCC were significantly thinner in all o...

INTRODUCTION Myopia presents a significant challenge to the ophthalmologist as myopic discs are often large, tilted, with deep cups and have a thinner neuroretinal rim all of which may mimic glaucomatous optic nerve head changes causing an error in diagnosis. OBJECTIVE To evaluate the retinal fiber layer (RNFL) thickness in low, moderate and high myopia using scanning laser polarimetry with v...