A genotoxic carcinogen, N-nitrosodimethylamine (NDMA), was detected as a synthesis impurity in some valsartan drugs 2018, and other N-nitrosamines, such N-nitrosodiethylamine (NDEA), were later sartan products. N-nitrosamines are pro-mutagens that can react with DNA following metabolism to produce adducts, O6-alkyl-guanine. The adducts result replication miscoding errors leading GC>AT mutations...

Background: According to several reports there is a positive correlation between the lowered quality of semen and any exposure to toxic compound specially those particularly disrupt endocrine functions. Like other herbicides atrazine (ATR) induces endocrine disruption and consequently interferes with sexual hormones physiological functions. Therefore current study was designed in order to evalu...