OBJECTIVE The aim of this investigation was to compare the pharmacokinetics of lidocaine and prilocaine in two groups of 10 patients undergoing intravenous regional anaesthesia. METHOD The study had a randomized design. The patients were allocated to one of the two groups of 10. Each group received either lidocaine (200 mg = 0.855 mM) or prilocaine (Citanest, 200 mg = 0.909 mM), injected intr...

This paper examines how the combination of simulated discharge and mean catchment residence time (MRT) may be used to subsume flow path process complexity and provide a simple, scalable evaluative data source for water quantity-quality based conceptual models at the catchment scale. A simple Monte Carlo framework is used to evaluate the identifiability of parameters, and how values of mean resi...

The method of analysis of the first temporal moment (mean residence time) of tracer return data was utilized to investigate the swept volume and fluid velocity between pairs of injection and production wells in the Dixie Valley geothermal field. Calculations were made using a spreadsheet program available from the Idaho National Laboratory. Jointly sponsored industry–government research at the ...

The aim of the study was to determine the apparent volume of distribution (VTOT), total body clearance (CL), fractional clearance, and mean residence time (MRT) of the β-cell hormone amylin. We therefore performed an intravenous injection of 50 μg of human synthetic amylin (amlintide) in nine healthy male subjects during suppression of endogenous amylin release by intravenous somatostatin (0.06...

Cotyledoside, a bufadienolide cardiac glycoside, was administered intravenously to sheep in 2 studies. In experiment 1, sheep (n = 4) received 0.0135 mg/kg daily on 5 consecutive days and in the 2nd experiment, sheep (n = 4) received 0.027 mg/kg as a single dose. Jugular blood was collected at different time intervals and kinetic parameters were determined. The data fitted a 1-compartmental mod...