This essay looks at the historical significance of six APS Classic Papers that are freely available on line: Malnic G, Klose RM, Giebisch G. Micropuncture study of renal potassium excretion in the rat. Am J Physiol 206: 674–686, 1964 (http://ajplegacy.physiology. org/cgi/reprint/206/4/674). Malnic G, Klose RM, Giebisch G. Micropuncture study of distal tubular potassium and sodium transport in r...