نتایج جستجو برای: repopulating
تعداد نتایج: 1209 فیلتر نتایج به سال:
BACKGROUND Hematopoietic stem cells (HSCs) or repopulating cells are able to self-renew and differentiate into cells of all hematopoietic lineages, and they can be enriched using the CD34 cell surface marker. Because of this unique property, HSCs have been used for HSC transplantation and gene therapy applications. However, the inability to expand HSCs has been a significant limitation for clin...
An understanding of mechanisms regulating hematopoietic stem cell engraftment is of pivotal importance to the clinical use of cultured and genetically modified transplants. Human cord blood (CB) cells with lymphomyeloid repopulating activity in NOD/SCID mice were recently shown to undergo multiple self-renewal divisions within 6 days in serum-free cultures containing Flt3-ligand, Steel factor, ...
Genetically marked peripheral blood progenitor cells were used to investigate their contribution to long-term hematopoietic reconstitution after autologous marrow and peripheral blood cell transplantation. After autologous marrow harvest and cryopreservation, canine peripheral blood progenitor cells were mobilized in three dogs by treatment with recombinant canine stem cell factor for 8 days. P...
UHRF proteins catalyze the ubiquitination of target and are involved in regulating gene expression. Some studies reported a reduced expression UHRF2 acute leukemia cells, but role hematopoiesis remains unknown. Here, we generated Uhrf2−/− mice to clarify deletion hematopoiesis. Compared Uhrf2+/+ mice, showed no differences complete blood counts, as well bone marrow (BM) findings spleen weights....
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