background: natural endometrium in frozen-thawed embryo transfer (fet) may have some benefits upon implantation in patients with repeated implantation failure (rif). it might be due to possible differences between natural and stimulated endometrial growth factors and cytokins secretions. objective: the objective of this study was to compare the pregnancy rate of fet on modified natural cycle ve...

Background: Because implantation failure is more frequent, many methods have been suggested to improve the implantation; however, their results have been inconsistent. One of the most hopeful methods is local endometrial injury. To explore the possibility that local injury of the endometrium increases the incidence of implantation and pregnancy rate in the subsequent IVF cycle in patients havin...

Background: HLA-G, as a tolerogenic molecule, expressed in cytotrophoblast cells and playing an important role in the suppression of the immune response in maternal decidua. Today Interaction of the extracellular domains of HLA-G protein with cell receptors of immune system, including CD8, LILRB1, LILRB2 and killer cell immunoglobulin-like receptor KIR2DL4, was well known. Materials and Methods...

background: despite major advances in assisted reproductive techniques, the implantation rates remain relatively low. some studies have demonstrated that intrauterine infusion of granulocyte colony stimulating factor (g-csf) improves implantation in infertile women. objective: to assess the g-csf effects on ivf outcomes in women with normal endometrial thickness. materials and methods : in this...

A prospective cohort study has been performed to find out if the administration of an oxytocin antagonist (Atosiban) at the occasion of embryo transfer has an effect on the pregnancy rate in patients with repeated failure of implantation. A total of 52 women with repeated failure of implantation after IVF/ICSI were included in this study. The ongoing pregnancy rate (OPR) in the total group of p...

Research question: Do miRNAs play a role in regulating endoplasmic Reticulum Stress (RS) and Unfolded Protein Response (UPR) decidualized cells endometrium associated with reproductive failures?Design: Endometrial stromal cell line St-T1b was vitro 8-Br-cAMP during 5 days, or treated the RS-inducer Thapsigargin (Tg). Expression of RS-sensors, UPR markers potential miRNA regulators were analysed...

In women undergoing in vitro fertilization (IVF) who have an implantation failure (IF) after repeated embryo transfer, an association with the presence of acquired thrombophilia has been demonstrated, and a thromboprophylaxis seems to be efficacious in improving implantation rate. More recently a role inherited trombophilia has been recognised to have a role in recurrent otherwhise unexplained ...