BACKGROUND There are few effective approaches to infertile patients with repeated failure in IVF-embryo transfer therapy. Since recent evidence suggests that some populations of maternal immune cells positively support embryo implantation, we have developed a new approach using peripheral blood mononuclear cells (PBMCs). METHODS Patients who had not experienced successful pregnancy despite fo...

A – Transmissible paternal/maternal genetic alterations:  Diseases that affect a single gene or monogenic (dominant, recessive or X-linked), whose mutation is known and can be analysed.  X chromosome-linked disorders, whose gene is not known or has some heterogeneity, but is avoided with sex selection.  Structural chromosomal abnormalities such as Robertsonian or reciprocal translocations. B...

We report three cases of effective management of infertility in women with a history of repeated unsuccessful IVF attempts, who have developed antibodies to hCG. A novel approach to conservative treatment of immunologic reproductive failure, suggested for selected patients, included membrane plasmapheresis, combined prednisolone, and intravenous immunoglobulin therapy. No adverse side effects w...

Deep brain stimulation (DBS) is a common surgical procedure used for the treatment of Parkinson's disease (PD) and essential tremor. A potential complication of this procedure is hardware failure. The authors report a case of DBS hardware failure in which repeated fractures of the extension wire were caused by abnormal rotational movements of the IPG placed in the loose subclavicular tissue of ...

  Purpose: Estrogen as a crucial hormone during pregnancy acts by two types of receptors.   Estrogen receptor alpha, expressed by estrogen receptor 1 (ESR1) gene, is more abundant and   exists in all human reproductive systems. Association of ESR1 gene polymorphism has been   shown in some reproductive fields such as spontaneous abortion, endometriosis-related infertility   and in vitro fertili...

Aim. To analyze the frequency and distribution of KIR genotypes in women with recurrent implantation failure after cycles vitro fertilization. Methods. DNA extraction purification, PCR-SSP, agarose gel electrophoresis. Results. The spectrum genes were determined. study group was divided according to history, particular, a 84 whose diagnosis outlined by concept "repeated failed implantations" si...

BACKGROUND Repeated implantation failure (RIF) is a major challenge in reproductive medicine and despite several methods that have been described for management, there is little consensus on the most effective one. OBJECTIVE This study was conducted to evaluate the effectiveness of platelet-rich plasma in improvement of pregnancy rate in RIF patients. MATERIALS AND METHODS Twenty women with...

BACKGROUND Decidualization is a prerequisite for successful implantation and the establishment of pregnancy. Krüppel-like factor 12 (KLF12) is a negative regulator of endometrial decidualization in vitro. We investigated whether KLF12 was associated with impaired decidualization under conditions of repeated implantation failure (RIF). METHODS Uterine tissues were collected from a mouse model ...