In the budding yeast, Saccharomyces cerevisiae, genes in close proximity to telomeres are subject to transcriptional silencing through the process of telomere position effect (TPE). Here, we show that the protein Ku, previously implicated in DNA double-strand break (DSB) repair and in telomeric length maintenance, is also essential for telomeric silencing. Furthermore, using an in vivo plasmid ...

Background: Intracranial pressure (ICP) control is one of the anesthesiologist challenges in craniosynostosis repair surgery, especially in multiple sutures involvement. The aim of this study was comparing the effect of two anesthesia methods including inhalation with hyperventilation and total intravenous anesthesia (TIVA) on ICP control and surgeon satisfaction in pediatrics with craniosynost...

Equipment logistics, maintenance, and repair are important aspects of construction equipment management. A well-managed equipment fleet helps reduce downtime, as well as total maintenance and repair costs. With quickly growing fleets of equipment, large contractors tend to divert the maintenance and repair of equipment from equipment managers to project managers. As a result, the equipment mana...

conclusions according to the findings, there has been a rise in the number of unsafe actions in machinery and maintenance service units compared to other maintenance units. as such, training courses based on the behavior-based safety principles at the beginning of employment, close monitoring of health safety environment (hse) officials on the implementation of regulations, and provision of app...