BACKGROUND Mesalamine or 5-aminosalicylic acid (5-ASA) has proven efficacy in treating patients with ulcerative colitis (UC). Although mesalamine is considered safe, it has been associated with acute interstitial nephritis and renal failure. METHODS Herein we present a case of a child with UC who developed acute renal failure on mesalamine therapy. RESULTS A 15-year-old African-American gir...

A 43 year old man with inoperable aortic coarctation and severe hypertension requiring near maximal anti-hypertensive treatment was admitted in severe heart failure. After 2 weeks of treatment the heart failure and blood pressure were incompletely controlled and angiotensin converting enzyme (ACE) inhibitor was started. Serum creatinine was normal before starting the ACE inhibitor and on discha...

Background: Recently, some shocking epidemics of chronic kidney disease of undetermined origin have been reported. In this regard, numerous lines of evidence suggest that socioeconomic and environmental stressors have a key role, an effect that needs further confirmation. The present study was undertaken to explore the effect of Chronic Unpredictable Stress (CUS) on kidney function and structur...

INTRODUCTION- Cardiovascular disease has emerged as a major health burden worldwide with coronary artery disease [CAD] causing highest mortality and morbidity. Coronary revascularization is the preferred treatment for patients with multivessel CAD. Based on the application of cardiopulmonary bypass [CPB], Coronary revascularization can be on-pump [OPCAB] or off-pump [CABG].The CPB is known to h...

obesity is accompanied with renal dysfunction, so renal impairment is more prevalent in obese people. renal function can be assessed via markers such as cystatin c (cys c), creatinine (crn) and glomerular filtration rate (gfr). as the effect of exercise training on renal function has been less investigated, this study aimed to study the effect of eight weeks of aerobic training and 10 days of d...

Objective: The incidence and prevalence of kidney stone is increasing worldwide. After the first recurrence the risk of subsequent relapses is higher and the time period between relapses is shortened. Urinary stones can be severely painful and make a huge economic burden. The stone disease may increase the vulnerability of patients to other diseases such as renal failure. Medicinal herbs are ri...

Increasing efferent renal sympathetic nerve activity (ERSNA) increases afferent renal nerve activity (ARNA), which decreases ERSNA to prevent sodium retention. High-sodium diet enhances ARNA, suggesting an important role for ARNA in suppressing ERSNA during excess sodium intake. Mean arterial pressure (MAP) is elevated in afferent renal denervated by dorsal rhizotomy (DRX) rats fed high-sodium ...

children suffering from decreased renal function may demand unique considerations regarding special oral and dental conditions they are encountered to. it is mentioned that renal function deterioration may affect the hard or soft tissues of the mouth. having knowledge about the high prevalence of dental defects, calculus, gingival hyperplasia, modified salivary composition and tissue responses ...

RATIONALE Compound 21 (C-21) is a highly selective nonpeptide AT2 receptor (AT2R) agonist. OBJECTIVE To test the hypothesis that renal proximal tubule AT2Rs induce natriuresis and lower blood pressure in Sprague-Dawley rats and mice. METHODS AND RESULTS In rats, AT2R activation with intravenous C-21 increased urinary sodium excretion by 10-fold (P<0.0001); this natriuresis was abolished by ...