Although the underlying mechanism is not elucidated, it has been postulated repeatedly that deprivation of sleep, particularly rapid eye movement (REM) sleep, affects learning. Here we report that memory for newly acquired information is impaired after a specific period of REM sleep deprivation (REMD). Memory retrieval-induced phosphorylation of protein kinases in the rat amygdala is abrogated ...

Although continued total sleep deprivation is fatal, the function of sleep remains a mystery. Shorter durations of sleep deprivation are followed by rebound increases in non-rapid eye movement (non-REM) sleep, suggesting a homeostatic control. Measurements of the power spectrum of the electroencephalograph (EEG) suggest that a more accurate marker of the homeostasis may be delta frequency power...

Several studies of sleep-breathing physiology have suggested that sleep deprivation may worsen obstructive sleep apnea. The aim of the study was to determine the direct effect of night work on breathing variables during sleep in fast-rotating shift workers. Twenty one men - police officers, fast-rotating shift workers, underwent polysomnography on 2 occasions: under a normal sleeping condition ...

Sleep deprivation has been shown recently to alter emotional processing possibly associated with reduced frontal regulation. Such impairments can ultimately fail adaptive attempts to regulate emotional processing (also known as cognitive control of emotion), although this hypothesis has not been examined directly. Therefore, we explored the influence of sleep deprivation on the human brain usin...

We hypothesize that REM sleep serves to upregulate and/or prevent downregulation of brain norepinephrine (NE) receptors. This hypothesis is based on the following observations: (1) NE neurons of the locus coeruleus (LC) are tonically active in waking and non-REM sleep, but the entire population of LC NE neurons is inactive during REM sleep. (2) Continuous presence of NE or adrenoceptor agonists...

Antidepressant medications, including ~cyclic antidepressants, monoamine oxidase inhibitors, lithium, and fluoxetine, generally have been found to suppress rapid eye movement (RFaM) sleep (yon Bardeleben et al. 1989, reviewed by Salem 1986), although several unusual antidepress~ts have been found to increase REM sleep (Wiegand et al. 1986; Di Peril et al. 1987; Soldatos et al. 1988; Monti 1989)...

According to the two-process model of sleep regulation, the timing and structure of sleep are determined by the interaction of a homeostatic and a circadian process. The original qualitative model was elaborated to quantitative versions that included the ultradian dynamics of sleep in relation to the non-REM-REM sleep cycle. The time course of EEG slow-wave activity, the major marker of non-REM...

* To whom all correspondence should be addressed Telephone: (443) 885-4687 Fax: (443) 885-8285 E-mail: [email protected] Running head: REM-sleep deprivation, metabolic rate, and UCP-1 gene expression