The purpose of this research was to prepare a floating matrix tablet containing domperidone as a model drug. Polyethylene oxide (PEO) and hydroxypropyl methylcellulose (HPMC) were evaluated for matrix-forming properties. A simplex lattice design was applied to systemically optimize the drug release profile. The amounts of PEO WSR 303, HPMC K15M and sodium bicarbonate were selected as independen...

Famotidine has been the most widely used drug for the treatment of peptic ulcer for many decades. The present investigation concerns the development and evaluation of floating tablets of famotidine which, after oral administration, are designed to prolong the gastric residence time, increase drug bioavailability and target the gastric ulcer. A floating drug delivery system (FDDS) was developed ...

the purpose of this work was to develop once daily sustained release (sr) matrix tablets of naproxen, an anti-inflammatory agent. the tablets were prepared by wet granulation method along with hydrophilic matrix materials like methocel k 15m cr and methocel k 100m cr. the granules were evaluated for bulk density, angle of repose, compressibility index, total porosity and drug content. the table...

This learning's objective is to determine and investigate how pharmaceutical restrictions affect the characteristics of gastric floating tablets using diclofenac sodium (DICL) as a model for solubility enhancement, sodium-bicarbonate (NaHCO3) or calcium-carbonate (CaCO3). Hydroxypropyl Methylcellulose (HPMC) swelling polymer K100M K15M gas-forming substance. BY direct-compression manufacturing ...

the aim of this study was to develop an extended-release tablet formulation using a new in situ cross-linking method. the effects of polyvalent cations on theophylline release from tablets made with the polyanionic polymers sodium alginate and sodium carboxymethylcellulose, were investigated. different miliequivalents of the di and tri-valent cation, ca2+ and al3+, were added to tablet formulat...

An inert hydrophobic buoyant coated-core was developed as floating drug delivery system (FDDS) for sustained release of cisapride using direct compression technology. Core contained low density, porous ethyl cellulose, which was coated with an impermeable, insoluble hydrophobic coating polymer such as rosin. It was further seal coated with low viscosity hydroxypropyl methyl cellulose (HPMC E15)...

The objective of the present investigation was to design a sustained release floating microcapsules of theophylline using two polymers of different permeability characteristics; Eudragit RL 100 (Eu RL) and cellulose acetate butyrate (CAB) using the oil-in-oil emulsion solvent evaporation method. Polymers were used separately and in combination to prepare different microcapsules. The effect of d...