Abstract Cancer and highly proliferating normal cells have high demand for energy but paradoxically switch production from the efficient mitochondrial respiration to low cytosolic glycolysis. This phenomenon is known as Warburg effect, reason which not fully understood. study found that intracellular pH (pHi) induced apoptosis, whereas pHi enhanced proliferation, of lymphocytes. In tumor cells,...

Abstract Apoptosis is a sequential order of cell death occurring regularly to ensure homeostatic balance between the rate formation and death. However, misplaced this balancing function can contribute an abnormal growth / proliferation or autoimmune disorders etc. therefore said be crucial from point development embryo throughout organism contributing renewal tissues also getting rid inflammato...

To investigate the effect of remimazolam on neuronal apoptosis in rat brain through slit guidance ligand 2/roundabout 4 signaling pathway. Primary cortical neurons were obtained from specific pathogen free 3 w old male Wistar rats and sub cultured cell culture dishes. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay detected viability; Hochest/propidium iodide double staining...

Klotho is a transmembrane protein which deficiency has pleiotropic effects in number of aging-related disease processes and various cancers. In some recent studies about klotho disorders, it been shown to effective cancers including lung, liver, breast, kidney, colon. TNF-related apoptosis-inducing ligand (TRAIL), TNF family molecule, cytokine that stimulates apoptosis through death receptors m...

Objective(s): Recent studies revealed that microRNAs (miRNAs) may play crucial roles in the responses and pathologic processes of spinal cord injury (SCI). This study aimed to investigate the effect and the molecular basis of miR-103 on LPS-induced injuries in PC12 cells in vitro and SCI rats in vivo. Materials and Methods: PC12 cells were exposed to LPS to induce cell injuries to mimic the in ...

Objective: To determine the effect of convallatoxin on K562 cell proliferation and apoptosis. Methods: CCK-8 assay was used to detect proliferation; PI staining, JC-1 Annexin V-FITC/PI double staining were analyze cycle, mitochondrial membrane potential, apoptosis; Western blotting cleaved caspase-9, caspase-3, Bcl-2, Bax, E2F1 expression Akt phosphorylation. Subsequently, AutoDock software int...

Abstract Objective Chondrocyte apoptosis plays a vital role in osteoarthritis (OA) progression. Angelica sinensis polysaccharide (ASP), traditional Chinese medicine, possesses anti-inflammatory and anti-apoptotic properties chondrocytes. This study aimed to determine the protective of ASP on sodium nitroprusside (SNP)-induced chondrocyte apoptosis, explore underlying mechanism. Method Human pri...

conclusions il-33 may be a potential new agent to attenuate rir injury by reducing inflammatory cell infiltration and preventing apoptosis. results our data revealed that il-33 pretreatment maintained a better retinal structure, inhibited leukocyte infiltration (il-33 vs. mg with p < 0.01 and il-33 vs. pbs group with p < 0.01), and reduced the apoptosis of retinal ganglion cells (il-33 vs. mg w...

introduction: busulfan as a chemotherapeutic agent causes testicular germinal epithelium depletion and cytotoxicity in germ cells. the aim of this study was to assess antioxidant status, reactive oxygen species (ros) generation and apoptosis-related genetic markers of adult male mouse sperm following busulfan treatment. materials and methods: forty adult nmri mice (30 ± 5 g) were divided into t...