OBJECTIVES We aimed to compare the efficacy of remission maintenance between infliximab "top-down" and "step-up" strategies in moderate to severe pediatric Crohn disease during 3 years. We also aimed to determine prognostic factors that may influence the relapse-free rate in these patients. METHODS The present study was a retrospective review of a prospective cohort, based on an infliximab tr...

BACKGROUND Methotrexate, a toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid, has been used to control autoimmune disease with different results. The aim of this study was to evaluate the effectiveness of low dose Methotrexate in the relapsing-remitting multiple sclerosis (RRMS). METHODS Eighty patients with definite RRMS aged 15 to 55 years were ...

This paper describes how a team who would work in the community with patients from the rehabilitation unit of Ljubljana psychiatric hospital was developed and what the results of treatment of a group of these patients were in terms of admission and relapse rate. The admission and relapse rate of these patients was markedly reduced by working assertively with them in the community.

abstract background: leukemia is the most common malignancy in childhood, and acute myeloid leukemia (aml) is the second most common leukemia.aml still accounts for more than 30% of deaths from leukemia. aml is classified into several subgroups from m0 to m7 with different presentations, clinical features, and outcomes. material and methods: between march 1996 and october 2003, 47 children with...

OBJECTIVE The objective of this study was to evaluate exposure to disease-modifying therapies (DMTs) during pregnancy in 335 pregnancies of multiple sclerosis (MS) patients and to further determine whether exclusive breastfeeding of MS mothers has any relevant influence on postpartum relapse rate. BACKGROUND Only limited data are available on whether DMT exposure during pregnancy affects rela...

OBJECTIVE The Lebanese Multiple Sclerosis (LeMS) study aims to assess the influence of pregnancy and delivery on the clinical course of multiple sclerosis (MS) in Lebanese women. SETTING This prospective multicentre study took place in three MS referral university medical centres in Lebanon. PARTICIPANTS Included were 29 women over 18 years who had been diagnosed with MS according to the Mc...

background : we conducted a retrospective analysis to investigate the clinical outcome of combined modality therapy using multiagent chemotherapy, nephrectomy, and radiotherapy in treatment of children with wilms' tumor. methods : this study was conducted on 91 cases of newly diagnosed wilms' tumor from january 2001 until february 2012. patients were categorized into two groups according to tre...