In the course of a study of the properties of the homogentisic acid oxidase of rat liver the activity of other animal tissues has been briefly examined. The enzyme has been reported to occur in beef and hog (I), guinea pig (2), and rabbit (3) livers and in a strain of Pseudomonas (4). The experiments reported here show that the enzyme is also present in pigeon liver and in guinea pig, rabbit, p...

For many years the major problem impeding the elucidation of the structure of melanin and the melanosome has been the insolubility of the melanin polymer. To date, alkaline and acid hydrolysis seem to be the only methods available which can completely solubilize the melanosome (1); unfortunately, both methods degrade the constituents of the organelle other than the melanin polymer. The recent e...

1. A reinvestigation of the methods for the purification of ox-spleen P-glucuronidase using the variable solvent solubility test has revealed the presence oftwo fractions having different pH optima. The two enzymes have been separated and purified by fractional precipitation with ammonium sulphate and shown to have the foll6wing pH optima: with 1-menthylglucuronide 4-5 and 5 0; phenylglucuronid...

Reinvestigation of the fermentation broth and mycelium of the fungus Phoma herbarum led to the isolation of a new phytotoxic nonenolide, namely, (7R,9R)-7-hydroxy-9-propyl-5-nonen-9-olide, which was designated with the trivial name herbarumin III (3). The known compounds herbarumins I (1) and II (2) were also obtained. The structure of 3 was elucidated by spectroscopic methods and molecular mod...

Recent progress in bacterial cytology has left no doubt as to the existence of a discrete nuclear body in bacterial cells. Numerous publications have appeared describing the appearance of apparent nuclear bodies in coccus forms, and descriptions of the activity of these bodies have been meticulously recorded. The literature on the nuclei of the cocci has been covered aptly by DeLamater and Wood...