Tissue engineering is an important technology for supporting regenerative medicine, producing tissues in incubation bottles in a tissue culture laboratory. In addition, a newer approach to regeneration of tissues in the human body, called in situ tissue engineering, has been devised in Japan and is attracting attention as a new means of bringing out our body’s potential. New therapeutic methods...

The salamander is the only tetrapod that regenerates complex body structures throughout life. Deciphering the underlying molecular processes of regeneration is fundamental for regenerative medicine and developmental biology, but the model organism had limited tools for molecular analysis. We describe a comprehensive set of germline transgenic strains in the laboratory-bred salamander Ambystoma ...

Application of combining herbal medicine and biomedical material science to nerve regeneration is a new approach. In this study, we describe a novel use of purified genipin, which can be extracted from Gardenia jasminoides Ellis, fixing the gelatin to be an extracellular matrix for peripheral nerve regeneration. A 10-mm gap of rat sciatic nerve was created between the proximal and distal nerve ...

in vertebrates and to determine the molecular and cellular basis for such currents. Methods: We use zebrafish caudal fin as an adult regeneration model. Specific ion flux measurements are done using a non-invasive Ion-Specific Scanning Microprobe coupled with transcriptional profiling and genetic functional analysis. Results: Our data points to an important role for protons (H[+]) during the re...

1 Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA 2Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, LA 70808, USA 3CNRS, UMR 5273, STROMALab, BP 84225, 31432 Toulouse, France 4Université de Toulouse, UPS, UMR 5273, STROMALab, BP 84225, 31432 Toulouse Cede...

Meniscus regeneration is an unsolved clinical challenge. Despite the wide acceptance of the degenerative consequences of meniscectomy, no surgical procedure has succeeded to date in regenerating a functional and long-lasting meniscal fibrocartilage. Research proposed a number of experimental approaches encompassing all the typical strategies of regenerative medicine: cell-free scaffolds, gene t...

MicroRNAs (miRNAs) have emerged as critical regulators of numerous biological processes by modulating gene expression at the post-transcriptional level. The discovery of miRNAs as new and important regulators of gene expression is expected to broaden our biological understanding of the regulatory mechanism in muscle by adding another dimension of regulation to the diversity and complexity of ge...