The influence of individual or combined treatments of the chloroacetanilide herbicide preti­ lachlor and the safener fenclorim on glutathione content and the activity of glutathione reduc­ tase (GR, EC 1.6.4.2) and glutathione-S-transferase (GST, EC 2.5.1.18) of rice (O ryza sativa L., var. Lamont) was investigated in a time-course study including 0, 12, 24, 48, and 72 h peri­ ods after treatme...

The interaction of the flavoprotein glutathione reductase from yeast with NADH has been studied. A reduced enzyme species resulting from addition of 2 electrons per enzymebound FAD is formed on addition of NADH to oxidized enzyme. This Z-electron reduced enzyme is stable toward further reduction to the 4-electron reduced state by excess NADH. Yeast glutathione reductase reduced by excess NADH h...

Methamphetamine (METH) abuse causes neurodegeneration. Medicinal herb such as crocin has neuroprotective properties. The current study evaluates the role of CREB-BDNF signaling pathway in mediating the neuroprotective effects of crocin against METH-induced neurodegeneration in rats. Sixty adult male rats were divided randomly into group 1 and group 2 which received 0.7 mL/rat ...

Paracetamol (acetaminophen, PCM) is a widely used over-the-counter analgesic and antipyretic drug. Intake of a large dose of PCM may result in severe hepatic necrosis. Oxidative stress is mediated by oxidative capacities of the PCM metabolite (N-acetyl-para-benzo quinoneimine, NAPQI), which covalently binds to proteins and other macromolecules to cause cellular damage. At low doses, NAPQI is ...

Methamphetamine (METH) abuse causes neurodegeneration. Medicinal herb such as crocin has neuroprotective properties. The current study evaluates the role of CREB-BDNF signaling pathway in mediating the neuroprotective effects of crocin against METH-induced neurodegeneration in rats. Sixty adult male rats were divided randomly into group 1 and group 2 which received 0.7 mL/rat ...