the aim of this study was to investigate the possible role of multiple inherited thrombophilic gene variations in women with unexplained spontaneous abortions. for this purpose, the factor v leiden (fvl) (rs6025), prothrombin g20210a (rs1799963), mthfr c677t (rs1801133), pai-1 4g/5g (rs1799889), ace i/d (rs1799752), enos e298d (rs1799983), and apo e e2/e3/e4 (rs429358) polymorphisms were genoty...

introduction: the majoritiy of abortion risk factors has been classified as environmental and vary from one place to another. this study aimed to explore the relationship between exposure to pesticides and spontaneous abortion among female pistachio farmers in rafsanjan, iran.   materials and methods: in this case-control study, 50 women with spontaneous abortion and 50 women without this histo...

PURPOSE To investigate the association of the HLA-A, -B and -DRB1 alleles with the occurrence of Recurrent Spontaneous Abortion. METHODS A case-control study of 200 women aged 18 to 35 years, consisting of a convenience sample of 100 women who had idiopathic recurrent spontaneous abortion and 100 women without abortion and with two or more children. Peripheral blood genomic DNA was extracted ...

Background & Aims: Recent evidences indicate that parts of the immunoregulation system such as CD4+CD25+Tcells (Treg) and Th2 cells and Th1 cells, play very important roles in the maintenance of pregnancy. The deficiency in proper recognition of fetal alloantigen by the maternal immune system is associated with recurrent pregnancy failure. Here, we investigate the proportional changes of CD4+CD...

To determine the overlaps of toxoplasmosis infection with serum luteinizing hormone level (s. LHL); we carried out this study on Baghdad women who suffered recurrent spontaneous abortion. Herein, a group of pregnant women aborted once (group I), and a second group who had multiple abortions (group II) were compared with a third group of normal pregnant women, which involved to serve as a contro...

a:4:{s:10:"Background";s:364:"Antiphospholipid syndrome is a coagulation disorder that causes recurrent miscarriages and fetal deaths. In the present review we summarize current knowledge about Antiphospholipid syndrome that associated with recurrent miscarriages. In addition, on the basis of these comprehensive data, possible pathophysiologic mechanisms of this disorder are discussed.";s:19:"M...

The majority of miscarriages are sporadic and most result from genetic causes that are greatly influenced by maternal age. Recurrent pregnancy loss (RPL) is defined by two or more failed clinical pregnancies, and up to 50% of cases of RPL will not have a clearly defined etiology.

it has been recognized that acute and chronic stress has an impact on the immune system. acute stress may have a stimulating effect on the immune system, while in the case of chronic stress specially depression, the immune system could be down-regulated. however, an association between depression and a higher number of circulating white blood cells with increased activity has been reported. ele...

background: mycoplasma infections are suggested as etiology of adverse pregnancy outcomes. objective: the aim of this study was to evaluate the association of mycoplasma hominis (m. hominis) infection and spontaneous abortion among pregnant women. materials and methods: in this case-control study that was conducted from august 2012 to january 2013, totally, 109 women were included with spontane...