OBJECTIVE (1) To develop an automated algorithm to predict a patient's response (ie, if the patient agrees or declines) before he/she is approached for a clinical trial invitation; (2) to assess the algorithm performance and the predictors on real-world patient recruitment data for a diverse set of clinical trials in a pediatric emergency department; and (3) to identify directions for future st...

The aim of this study was to test the hypothesis that the mechanism of recruitment and the lower knee of the pressure-volume curve in the normal lung are primarily determined by airway reopenings via avalanches rather than simple alveolar recruitments. In isolated dog lung lobes, the pressure-volume loops were measured, and crackle sounds were recorded intrabronchially during both the first inf...

Methods and results One significant issue for surgical trials is to ensure surgeons recruiting to the trial are over their initial ‘learning curve’. To ensure surgeon competency and minimise any ‘learning curve’ effect, ROLARR only includes surgeons who have performed at least 30 rectal cancer resections (minimum of 10 for each procedure). Randomisation also stratifies by surgeon to ensure bala...

In this work, we re-evaluated long-standing conjectures as to the source of the exceptionally large compliance of the bladder wall. Whereas these conjectures were based on indirect measures of loading mechanisms, in this work we take advantage of advances in bioimaging to directly assess collagen fibers and wall architecture during biaxial loading. A custom biaxial mechanical testing system com...

the relevance and effectiveness of the world health organization’s (who’s) global code of practice on the international recruitment of health personnel is being reviewed in 2015. the code, which is a set of ethical norms and principles adopted by the world health assembly (wha) in 2010, urges members states to train and retain the health personnel they need, thereby limiting demand for internat...

INTRODUCTION Studies comparing high frequency oscillatory and conventional ventilation in acute respiratory distress syndrome have used low values of positive end-expiratory pressure and identified a need for better recruitment and pulmonary stability with high frequency. OBJECTIVE To compare conventional and high frequency ventilation using the lower inflection point of the pressure-volume c...

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