The first successful treatment of growth hormone (GH) deficient children with GH extracted from human pituitary was introduced during late 1950's.  The subsequent availability and use of recombinant GH (rhGH) for different clinical conditions raised the question of whether this new therapeutic modality increases the risk of certain conditions such as leukemia or malignancy.  Herein, we report o...

Protein splicing is a post-translational autocatalystic excision of internal protein sequence (intein) with the subsequent ligation of the flanking polypeptides (exteins). The high specificity of excision ensured by intein makes it possible to use a phenomenon of protein splicing for the biotechnology purposes. The aim of this work was optimization of obtaining and purification of the recombina...

Pituitary gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) play central roles in regulating gametogenesis and the production of gonadal hormones, in fish as in other vertebrates. Pituitary gonadotropins are composed of two non-covalently associated polypeptide subunits, which must be glycosylated, folded, and assembled as a heterodimer to be biologically active. Si...

Abstract: To serve health care, up to now, sciences have successfully developed many drugs with different effects. In general, in terms of chemical structure and effect characteristics, medicine can be classified into groups including inorganic drugs, small-molecule organic protein (macromolecules), recently a new group has been formed, separate from the drug class, which is RNA drugs. pharmaco...

Background To compare two different gonadotropin preparations, human menopausal gonadotropin (hMG) and recombinant follicle-stimulating hormone (rFSH), combined with clomiphene citrate (CC) in women with unexplained infertility undergoing intrauterine insemination (IUI). MaterialsAndMethods In this prospective clinical trial, couples prepared for IUI cycles were randomly allocated to two groups...