Introduction Anakinra is a recombinant, non-glycosylated form of the human IL-1 receptor antagonist, which recently was approved in US for neonatal onset multisystem inflammatory disease (NOMID), the most severe form of the Cryopyrin-Associated Periodic Syndromes (CAPS). This autoinflammatory disease can be effectively controlled by daily subcutaneous administrations of Kineret[1-3]. The recomm...

background: the purpose of present study was to evaluate the role of pre-ovulatory gnrh agonist therapy on ivf outcomes in gnrh antagonist cycles. methods: in this prospective study we recruited 100 infertile women undergoing ivf cycles with gnrh antagonists. the patients were assigned to two groups: group a (the study group, n=42) were assigned for receiving hcg+triptorelin for the final oocyt...

We used recombinant adeno-associated virus (rAAV)-mediated gene delivery to overexpress a mutant of rat leptin yielding a protein that acts as a neutral leptin receptor antagonist. The long-term consequences of this overexpression on body weight homeostasis and physical activity, as assessed by voluntary wheel running (WR), were determined in F344 x Brown Norway (BN) rats. Leptin antagonist ove...

objective(s) cannabinoids have been implicated in memory deficit. we examined the effect of am281, cannabinoid antagonist/inverse agonist in prevention of scopolamine-induced cognitive deficit. materials and methods  object recognition task was used to evaluate memory in mice. exploration time in the first and the second trial was recorded. the differences in exploration between a previously se...

Clinical outcomes of dual trigger containing gonadotropin-releasing hormone agonist (GnRHa) and low dose human chorionic gonadotropin (hCG) compared with the standard for final oocyte maturation in normal responder patients GnRH Antagonist IVF-ICSI Cycles. A single centre prospective randomized comparative study conducted at a tertiary care infertility , Akanksha IVF centre, Janakpuri, New Delh...

Abstract Introduction The orexin neuropeptide–receptor system is a central sleep and wake regulator in the brain. two receptor subtypes, OX1R OX2R, are expressed either alone or together all major wake-promoting brain areas. OX2R activation by orexins causes elevation of intracellular calcium, which enhances synaptic transmission secondary, monoaminergic wake- arousal-promoting neurotransmitter...

OBJECTIVE To demonstrate the inhibitory function of the prodomain of tumor necrosis factor-alpha (TNF-alpha) converting enzyme (TACE) on TACE activity and to develop an approach to interfere with inflammation processes. METHODS The cDNA encoding the full-length ectodomain (T1300) and prodomain (T591) of TACE were amplified by RT-PCR. The expression plasmids (pET-28a (+)-T1300 and pET-28a (+)-...