نتایج جستجو برای: receptor type 22
تعداد نتایج: 1945290 فیلتر نتایج به سال:
antiemetics are given to cancer patients prior to their chemotherapy sessions to protect them from nausea and vomiting induced by chemotherapy. the responsible health care team member will choose the type of antiemetic required to prevent the patient from developing nausea and vomiting according to the chemotherapy ematogenicity level. current guidelines recommend using a single antiemetic agen...
background : this study evaluates estrogen and progesterone expressions in patients with ovarian tumors (both benign and malignant) and their correlation with various clinicopathological prognostic parameters. receptors for estrogen and progesterone are predictive and prognostic markers of endometrial and breast cancers. however, their clinical significance in epithelial ovarian cancer is not c...
IL-22 has been identified as a cancer-promoting cytokine that is secreted by infiltrating immune cells in several cancer models. We hypothesized that IL-22 regulation would occur at the interface between cancer cells and immune cells. Breast and lung cancer cells of murine and human origin induced IL-22 production from memory CD4+ T cells. In the present study, we found that IL-22 production in...
Background: Breast cancer is the most commonly diagnosed and the leading cause of cancer death among females worldwide. The rate of breast cancer incidence among Iranian women is 17% of all cancers, it has been ranked first in Iran. This study aimed to investigate the factors affecting axillary lymph node involvement in female patients with breast cancer. Methods: A cross-sectional study was c...
Pathological Gambling Disorder Associated With Modafinil Therapy in a Patient With Type 1 Narcolepsy
We report the case of a 22-year-old man with type 1 narcolepsy who experienced pathological gambling after modafinil therapy. The patient was administered modafinil, which improved excessive daytime sleepiness (EDS). However, he heart palpitations and nervousness, eventually developing addiction. After six months therapy, engaged in various online activities, leading to significant financial lo...
Acetylcholine activates nicotinic acetylcholine receptors (nAChRs) by binding at an extracellular orthosteric site. Previous studies have described several positive allosteric modulators (PAMs) that are selective for homomeric α7 nAChRs. These include type I PAMs, which exert little or no effect on the rate of receptor desensitisation, and type II PAMs, which cause a dramatic loss of agonist-in...
stroke is the leading cause of death and disability in the world after the cancer and cardiovascular diseases. genetic factors have main significance to got stroke. renin-angiotensin system contains candidate genes and polymorphisms for causing stroke. there are reported associations between stroke and angiotensin ii type-1 receptor g. 1166a > c polymorphism (rs5186). therefore in this study th...
Newly identified T helper cell 22 (Th22) is a subset of CD4+ T cells with specific properties apart from other known CD4+ T cell subsets. Th22 is obviously discrete from Th17 and Th1 subsets by production of interleukin (IL)-22 but not IL-17 or IFN-γ, and also with distinguished expression of aryl hydrocarbon receptor (AHR) as the key transcription factor. This T helper subset, by producing pro...
estrogen might play an important role in the pathogenesis of diabetes mellitus type 2. estrogens inhibit diabetes via distinct mechanisms particularly by reducing both hyperglycemia and plasma insulin levels. estrogen exerts its physiological effects mainly through estrogen receptors including α and β types. estrogen receptors are found in many tissues that participate in the pathogenesis of ty...
The human insulin receptor is encoded by a single gene with 22 exons, and it is a membrane protein composed of two α and two β subunits (1). Binding of insulin to the extracellular α subunit causes a conformational change, leading to the activation of tyrosine kinase at the intracellular β subunit as well as the autophosphorylation of the receptor, followed by the activation of signal transduct...
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