BACKGROUND Type 2 diabetes mellitus is an important risk factor for Alzheimer disease and is more prevalent in elderly minority persons compared with non-Hispanic white persons. OBJECTIVE To determine whether diabetes is related to a higher risk of mild cognitive impairment (MCI), a transitional stage between normal cognition and Alzheimer disease, in a multiethnic cohort with a high prevalen...

OBJECTIVE To explore whether hypertension is associated with the risk of mild cognitive impairment (MCI), an intermediate stage of dementia, because there are conflicting data relating hypertension to the risk of Alzheimer disease. DESIGN AND SETTING Prospective community-based cohort study conducted in northern Manhattan. Multivariate proportional hazards regression analyses were used, relat...

Objective: Aim of the present review study was to describe and compare neurocognitive features MCI which could predict its progression DLB vs AD. Background: Progression AD or is a relatively recent field with emphasis on clinical neuropsychological potentially specific types dementia. Methods: A literature in Pubmed database has been made, after year 2005, using key- words: assessment; MCI; AD...

Cognitive scientists have increasingly turned to cultural transmission to explain the widespread nature of religious representations. One key hypothesis focuses on memory, proposing that that minimally counterintuitive (MCI) content facilitates the transmission of supernatural beliefs. We propose two caveats to the MCI hypothesis: 1) distinctiveness, and therefore memory, decreases as MCI conce...

BACKGROUND The impact of cognitive impairment on activities of daily living (ADL) is being used as a major criterion for differentiating between mild cognitive impairment (MCI) and dementia. The concept of an ADL threshold that separates MCI from dementia, however, appears to be improbable for several reasons. OBJECTIVES To determine whether complex ADL are impaired in patients with MCI; to e...

Mild cognitive impairment (MCI) was defined by Petersen et al. (1999) as progressive memory loss, a prodrome of Alzheimer's disease. MCI is a well-established entity that can be both a diagnosis in medical practice and a valid target of Alzheimer's prevention therapy. More recently MCI has expanded to include other cognitive domains with other potential causes: amnestic MCI, multiple domains MC...

In this work, we propose a novel subclass-based multi-task learning method for feature selection in computer-aided Alzheimer's Disease (AD) or Mild Cognitive Impairment (MCI) diagnosis. Unlike the previous methods that often assumed a unimodal data distribution, we take into account the underlying multipeak distribution of classes. The rationale for our approach is that it is highly likely for ...

BACKGROUND Previous literature demonstrates the interest of gait analysis to predict cognitive decline in old people. AIMS This pilot study aims to determine if gait speed or gait variability is a marker able to early identify, among mild cognitive impairment (MCI) subjects, those at risk to develop Alzheimer's disease (AD) in the future. METHODS 13 MCI subjects were included in 2007. Their...

Compared to cognitively healthy ageing (CH), intra-individual variability in reaction time (IIV(RT)), a behavioural marker of neurological integrity, is commonly reported to increase in both Alzheimer's disease (AD) and mild cognitive impairment (MCI). It varies in MCI with respect to whether it represents the pro-dromal stages of dementia or not; being greatest in those most likely to convert....