INTRODUCTION Phosphate binding with sevelamer can ameliorate detrimental histomorphometric changes of bone in chronic renal insufficiency (CRI). Here we explored the effects of sevelamer-HCl treatment on bone strength and structure in experimental CRI. METHODS Forty-eight 8-week-old rats were assigned to surgical 5/6 nephrectomy (CRI) or renal decapsulation (Sham). After 14 weeks of disease p...

To estimate multipliers linking surveillance of salmonellosis, campylobacteriosis, and Shiga toxin-producing Escherichia coli (STEC) infections to community incidence, we used data from a gastroenteritis survey and other sources. Multipliers for severe (bloody stool/long duration) and milder cases were estimated from the component probabilities of doctor visit, stool test, sensitivity of labora...

The cellular interactions in the anti-p-azobenzenearsonate (ABA) 1 suppressor T cell pathway, for the inhibition of ABA-specific delayed-type hypersensitivity and cytotoxic T cell responses, are restricted by Igh-linked genes (reviewed in 1). The inducer, Ts-1 (T suppressor cell), and the effector, Ts-3, suppressor T cells, and one of their factors (TsF1) bear the major crossreactive idiotypic ...

The idiotypic determinants on IgM rheumatoid factor (RF) from a single family have been analyzed. Rabbit Fab'2 antiidiotypic antibody was prepared against purified IgM-RF from a patient with rheumatoid arthritis. As measured by radioimmunoassay, the antiidiotype reacted with at least 90% of the patient's RF, but not with non-RF immunoglobulins from the same serum, nor with 10 of 11 polyclonal a...

Understanding how hash functions can be used in a sound manner within cryptographic protocols, as well as how they can be constructed in a sound manner from compression functions, are two important problems in cryptography with a long history. Two approaches towards solving the first problem are the random oracle model (ROM) methodology and the UCE framework, and an approach to solving the seco...

These studies were performed to assess the utility of the baboon as a nonhuman primate model to evaluate vaccines for use in humans. Specifically, we examined the antibody response of baboons immunized during the third trimester of pregnancy with Haemophilus influenzae type b (Hib) polyribosylribitol phosphate (PRP) conjugate and unconjugated polysaccharide vaccines. Some of the vaccinated moth...

Two studies addressed the implications of concordance versus discrepancy of attachment representations in individuals at 2 stages in their marital relationships. Engaged (n = 157) and dating (n = 101) couples participated in a multimethod 6-year longitudinal study of adult attachment. Individuals completed the Adult Attachment Interview (AAI), the Current Relationship Interview (CRI), and vario...

BACKGROUND Multiple treatments for painful diabetic peripheral neuropathy are available. PURPOSE To evaluate the comparative effectiveness of oral and topical analgesics for diabetic neuropathy. DATA SOURCES Multiple electronic databases between January 2007 and April 2014, without language restriction. STUDY SELECTION Parallel or crossover randomized, controlled trials that evaluated pha...

Following replacement therapy with coagulation factor VIII (FVIII), up to 30 % of haemophilia A patients develop FVIII-specific inhibitory antibodies (FVIII inhibitors). Immune tolerance induction (ITI) is not always successful, resulting in a need for alternative treatments for FVIII inhibitor-positive patients. As tolerance induction in the course of ITI appears to involve the formation of an...