RATIONALE Conjunctival lymphoproliferative lesions constitute a significant diagnostic challenge and it is essential to exclude neoplastic lesions. Histopathological and immunohistochemical tests are very useful in establishing the correct diagnosis. Reactive lymphoid hyperplasia (RLH) is part of a spectrum of lymphocytic infiltrative disorders. Evidence is scarce regarding appropriate treatmen...

Topical application of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to SENCAR mouse skin results within 48 h in a 3-fold elevation of xanthine oxidase (XO) activity, an enzyme capable of generating the reactive oxygen species superoxide and hydrogen peroxide. The antiinflammatory steroid fluocinolone acetonide, an inhibitor of TPA-induced hyperplasia, as well as the multiple st...

introduction: most b-cell malignancies are diagnosed based on morphologic and immunohistochemical criteria. some cases, however, still present a challenge for the pathologist to discriminate between reactive hyperplasia and neoplastic disorders. molecular techniques can be used as a helpful diagnostic tool in these cases. in this study, we assessed the value of polymerase chain reaction (pcr) t...

Context Nodular lymphoid hyperplasia is a disease may that occur in multiple locations including the gastrointestinal tract. Few reports exist on the occurrence in the hepatopancreaticobiliary system, and yet this has not been reported in the bile duct. Case report A fiftyseven-year-old male presented with painless jaundice, intra-hepatic biliary dilatation and a lesion in the distal pancreas (...

We report an unusual case of angioimmunoblastic T-cell lymphoma (AITL) progressing rapidly from Epstein-Bar virus (EBV)-associated paracortical hyperplasia with T-cell oligoclones, which caused the patient to die within only 1 month. The patient was a 67-year-old Chinese man with 3 month’s history of rhinorrhea, pruritus and superficial lymphadenopathy. In the first biopsy, morphology and immun...

We report on a case of focal haematopoietic hyperplasia occurring in the haematopoietic marrow in a lumbar vertebral body, of a young man. The PET scan performed showed high uptake of the radiotracer in the vertebral body of L3 and a MRI of the lumbar spine confirmed the vertebral lesion. A biopsy of the L3 vertebral body lesion was performed and the histological result was of chronic myeloprol...