AIM To conduct a meta-analysis of randomised clinical trials (RCTs) in order to evaluate the development of conjunctival hyperaemia after the use of latanoprost versus travoprost and bimatoprost, in patients with ocular hypertension or glaucoma. METHODS In order to identify the potentially relevant RCTs, a systematic literature retrieval was conducted in Medline, Embase and Cochrane Controlle...

As part of a larger study on the interpretation of angiographically derived hemodynamic parameters, blood flow in several ocular tissues was measured using the radioactively labelled microspheres technique. As an unexpected secondary results, it was found that the microspheres data gave quantitative information on hyperaemic effects in the eye. This is the subject of the present paper. The meas...

Vulnerability of the heel to ulceration in bed-bound persons is related to direct pressure-induced blood flow decreases. Periodic pressure reduction is a clinical strategy to help prevent ulcers by allowing flow-repayment hyperaemia that has a magnitude and duration thought to be related to the duration of the prior interval of ischaemia. However, there are reasons to question whether effects o...

BACKGROUND Glucose intolerance is a major health problem and is associated with increased risk of progression to type 2 diabetes mellitus and cardiovascular disease. However, whether glucose intolerance is related to impaired myocardial perfusion is not known. The purpose of the present study was to study the effect of diet-induced glucose intolerance on myocardial function and perfusion during...

Instruction: Measurement of brachial artery diameter variation by ultrasound methods has commonly been used to test the endothelial function. It is known that the artery diameter is increased by flow stimulation. Therefore in the present study, the effect of external obstruction, as flow stimulation, on the radial strain of the brachial artery was assessed. Also the biomechanical behavior of...

Characterization of temperature and thermal transport properties of the skin can yield important information of relevance to both clinical medicine and basic research in skin physiology. Here we introduce an ultrathin, compliant skin-like, or 'epidermal', photonic device that combines colorimetric temperature indicators with wireless stretchable electronics for thermal measurements when softly ...

OBJECTIVE The aim was to investigate whether impaired coronary flow reserve associated with cardiac hypertrophy could significantly limit the flow debt repayment following short periods of coronary occlusion and exacerbate or prolong episodes of myocardial ischaemia. METHODS Left ventricular hypertrophy was induced in guinea pigs by aortic constriction and the hearts were isolated six weeks l...

1. Resting forearm blood flow was increased in untreated juvenile diabetics and a slight but significant reduction took place during insulin treatment. The peak flow after ischaemia was also increased, but no difference could be demonstrated before and after insulin administration. 2. Reactive hyperaemia was found to be considerably prolonged in the diabetic patients with moderate ketosis and m...

Endothelial dysfunction is an important contributor to atherosclerosis and cardiovascular disease. However, routine assessment via angiography or flow-mediated dilation is difficult due to technical limitations. Peripheral arterial tonometry (PAT) is a promising alternative method for non-invasive assessment of endothelial dysfunction. This study assessed the test-retest reliability of PAT in a...