Radixin (RDX) is part of the ezrin-radixin-moesin (ERM) protein family. It functions as a membrane-cytoskeletal linker in actin-rich cell surface structures and is thought to be essential for cortical cytoskeleton organization, cell motility, adhesion, and proliferation. An increase in phosphorylated ERM in fibroblast-like synoviocytes contributes to rheumatoid arthritis (RA) synovial hyperplas...

Soils in Technical Area 16 at Los Alamos National Laboratory (LANL) are severely contaminated from past explosives testing and research. Our objective was to conduct laboratory and pilot-scale experiments to determine if zerovalent iron (Fe(0)) could effectively transform RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) in two LANL soils that differed in physicochemical properties (Soils A and B)....

Explosive compounds have been released into the environment during manufacturing, handling, and usage procedures. These compounds have been found to persist in the environment and potentially promote detrimental biological effects. The lack of research on bioaccumulation and bioconcentration and especially dietary transfer on aquatic life has resulted in challenges in assessing ecological risks...

Abstract Soil and water get polluted with hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) during its manufacturing, storage use for civil military purposes. RDX has toxic effects on living non-living environment is a recalcitrant compound. Therefore, the remediation of this compound necessary. Microbial degradation can be suitable sustainable option to reduce deleterious impact environment. optim...

Hexahydro-1,3,5-trinitro-1,3,5,-triazine (RDX) is a cyclic nitramine explosive that is a major component in many military high-explosive formulations. In this study, we developed a real-time TaqMan polymerase chain reaction (PCR) that targets the xplA functional gene involved in the breakdown/transformation of RDX. The xplA gene, described previously [Seth-Smith, H.M., Rosser, S.J., Basran, A.,...

BACKGROUND Although microRNAs (miRNAs) have been found to play an important role in many biological and metabolic processes, their functions in animal response to environmental toxicant exposure are largely unknown. OBJECTIVES We used hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), a common environmental contaminant, as a toxicant stressor to investigate toxicant-induced changes in miRNA expre...

Molecular dynamics simulations were carried out to study the effects of interface interactions between a crystalline structure and a plastic bonded explosive (PBX) system. In this work, the hydroxyl-terminated polybutadiene (HTPB) represents the polymer, isophorone diisocyanate (IPDI) is the diisocyanate and dioctyl adipate (DOA) is the plasticizer. Two different crystal high explosives compone...

Perchlorate, an oxidizer routinely used in solid rocket motors, is easily washed out of old motors. The washout operation, however, leads to wastewater containing perchlorate. Royal Demolition Explosive (RDX), a major component of military high explosives, is transferred to Army industrial wastewaters during assembly of new munitions and during demilitarization of old munitions. New high explos...