The retinoblastoma gene, RB-1, was the first identified tumor suppressor. Rb(-/-) mice die in mid-gestation with defects in proliferation, differentiation and apoptosis. The activating E2F transcription factors, E2F1-3, contribute to these embryonic defects, indicating that they are key downstream targets of the retinoblastoma protein, pRB. E2F4 is the major pRB-associated E2F in vivo, yet its ...

The present study aimed to investigate the association between the expression of sex-determining region Y box 2 (SOX2) in retinoblastoma (Rb) tissues and peripheral blood, and the clinicopathological characteristics of Rb. The expression of SOX2 in Rb tissues was detected by immunohistochemical staining and western blot analysis. SOX2 expression in the peripheral blood of children with Rb was d...

Rb(+/+):Rb(-/-) chimeric mice are healthy until early in adulthood when they develop lethal pituitary tumors composed solely of Rb(-/-) cells. In an effort to delineate the minimal structures of the retinoblastoma protein necessary for RB tumor suppression function, chimeric animals derived from stably transfected RB(-/-) embryonic stem (ES) cells were generated. One such ES cell transfectant e...

Inactivation of multiple endocrine neoplasia (MEN) type 1 gene (Men1) results in development of multiple endocrine tumors in Men1(+/-) mice and in humans. Intriguingly, loss of the wild-type retinoblastoma 1 (Rb) gene also leads to MEN-like phenotype in Rb(+/-) mice. To evaluate potential genetic interactions between these genes, we prepared and characterized Men1(+/-)Rb(+/-) compound mice in p...

Inductor Inductor Capacitor (LLC) resonant converter has gained attention of researchers and engineers these days High efficiency, power density and Reliability. LLC resonant converter is most suitable resonant converter for front end DC-DC applications. Integrated magnetic, ZVS and high frequency operation, make the converter more compact and efficient. In this paper brief analysis of the LLC ...

This paper proposes a stand-alone photovoltaic (PV) system based on a DC-DC positive output super lift Luo (POSLL) converter. A conventional sliding mode control, a sliding mode controller using a simple sign function and a linear controller using proportional integrator (PI) are used for the control of the PV panel voltage and POSLL converter inductor current and these methods are compared tog...

In this paper, KY converter and voltage gain enhanced KY converter are included. A KY converter is a voltage step up converter, it can be considered as a buck converter along with synchronous rectification. In general, a KY converter consists of two MOSFET switches. To obtain higher voltage gain we can adopt different methods. Some of these techniques, advantages and disadvantages of each metho...

The paper proposes a three phase, two switch buck type converter with high power factor.The key feature of the proposed converter is that a switch in the converter has a lower peak voltage stress than a switch in a conventional threephase, single-switch buck-converter. A switch in the converter sees a line to neutral voltage across it rather than a line to line voltage which is the case for the...

A new three-level ac–dc single-stage converter that can operate with standard phase-shift pulse width modulation is proposed in this letter. In this letter, the operation of the converter is explained, and its feasibility is confirmed with experimental results obtained from a prototype converter. Finally, the efficiency of the new converter is compared with that of a previously proposed convert...

For beneficiation of converter slag, the role of surface phenomena on slag composition was studied. This work includes some experimental data, which were measured for basic oxygen steel (BOS) slag in Isfahan Steel Plant. All data were collected on site in the plant. The results support the idea that surface activity plays a major role in converter slag formation. It was also a new finding t...