The rat sciatic nerve is a well-established model for the study of recovery from peripheral nerve injuries. Traditional methods of assessing nerve regeneration after nerve injury and repair, such as electrophysiology and histomorphometry, despite widely used in neural regeneration experiments, do not necessarily correlate with return of motor and sensory functions. The aim of this experimental ...

BACKGROUND Intraneural injection during nerve-stimulator-guided sciatic block at the popliteal fossa may be a common occurrence. Although intraneural injections have not resulted in clinically detectable neurologic injury in small studies in human subjects, intraneural injections result in postinjection inflammation in animal models. This study used clinical, imaging, and electrophysiologic mea...

Objectives: Crocin and safranal, the major constituents of saffron, exert neuroprotective effects. In the present study, we investigated the effects of crocin and safranal  (alone or in combination with insulin) on peripheral neuropathy in diabetic rats. Materials and Methods: Diabetes was induced by intraperitoneal (i.p.) injection of 60 mg/kg of streptozotocin (STZ) and confirmed by blood glu...

Clonidine has been shown to prolong sensory analgesia when given as an adjunct to peripheral nerve blocks but has not been evaluated when given in conjunction with a femoral-sciatic nerve block. The purpose of this investigation was to determine whether the addition of clonidine to a femoral-sciatic nerve block would prolong the duration of sensory analgesia in groups of patients undergoing ant...

Sciatic nerve shows many variations in its division, especially its high division. This variation (high division of sciatic nerve) may results in sciatica, nerve injury during deep intramuscular injections in gluteal region, piriformis syndrome, and failed sciatic nerve block in anaesthesia. A very unusual case of two different types of high divisions of sciatic nerve on either side of an adult...

Axotomy of the sciatic nerve have been documented to cause neuronal loss, especially in newborn rats. Few works have focused on time course of neuronal loss and the type of cell death, which occurs after axotomy. Forty rat pups were anesthetized by hypothermia and the right sciatic nerve transected at five days of their age and the left side was used as control. The operated animals were sacrif...

Diabetes mellitus produces marked abnormalities in motor nerve conduction, but the mechanism is not clear. In the present study we hypothesized that in the streptozotocin (STZ)-induced diabetic rat impaired vasodilator function in arterioles that provide circulation to the region of the sciatic nerve is associated with reduced endoneural blood flow (EBF) and that these defects precede slowing o...

BACKGROUND Local anesthetics that produce analgesia of long duration with minimal impairment of autonomic functions are highly desirable for pain management in the clinic. Prenylamine is a known calcium channel blocker, but its local anesthetic blocking effects on voltage-gated sodium channels have not been studied thus far. METHODS The authors characterized the tonic and use-dependent prenyl...

OBJECTIVES In this randomized, controlled, blind study, a combined sciatic-femoral nerve block with levobupivacaine was compared with a unilateral spinal anaesthesia with respect to effectiveness, patient and surgeon satisfaction, and the effect on postoperative pain in arthroscopic knee surgery. METHODS Patients were randomly divided into two groups. Group I (n=20) received a combined sciati...

Axotomy of the sciatic nerve have been documented to cause neuronal loss, especially in newborn rats. Few works have focused on time course of neuronal loss and the type of cell death, which occurs after axotomy. Forty rat pups were anesthetized by hypothermia and the right sciatic nerve transected at five days of their age and the left side was used as control. The operated animals were sacrif...