Vitamin K is a substrate for the enzyme catalyzing the carboxylation of specific glutamyl residues to y-carboxyglutamy1 residues in hepatic precursors of a limited number of plasma proteins, including prothrombin. The y-carboxylation of these proteins can be blocked by the anticoagulant warfarin; and in the bovine and human, warfarin treatment results in the secretion of under-y-carboxylated fo...

objective: stevioside is a natural non-caloric sweetener which has been reported to have anti-inflammatory activity.  the aim of  the present study was to examine in vitro and in vivo effects of  stevioside on rats  plasma levels of tumor necrosis factor- α (tnf-α),  interleukin-1β (il-1β), tnf-α and il-1β release from lipopolysaccharide(lps)-stimulated rat peripheral blood mononuclear cells (p...

addition of n-butyl nitrite to isolated rat hepatocytes caused an immediate glutathione depletion followed by an inhibition of mitochondrial respiration, inhi- bition of glycolysis and atp depletion. at cytotoxic butyl nitrite concentrations, lipid  peroxidation  occurred  before  the  plasma  membrane  was  disrupted. cytochrome p-450 inhibitors inhibited peroxynitrite formation and prevented ...

Rat and guinea pig liver microsomes labeled with phospholipid (32)P were incubated with rat, guinea pig, and rabbit plasma in a KCl-Tris-EDTA buffer. A net transfer of microsomal phophatidylcholine and phosphatidylethanolamine to plasma was observed. In addition, an exchange of phospholipids between microsomes and plasma took place. During 20-min incubations at 37 degrees C, the exchange of pho...

1. Theoretically, the method of cultivating tissues outside the body offers an ideal technique for the demonstration and study of cytotoxins. 2. Mouse sarcoma, which grows vigorously in the plasma of normal rats, shows little or no activity in the plasma of rats immunized by mouse sarcoma injections. 3. Rat sarcoma, readily cultivated in the plasma of normal guinea pigs, either remains quite in...

By DOROTHEA ZUCKER-FRANKLIN, EDWARD C. FRANKLIN AND NORMAN S. COOPER T HE ROLE of the plasma cell in the synthesis of y-globulin has been readily accepted because of the excellent correlation found between the number of plasma cells in tissues, the ability to form antibodies, and the level of y-globulin in the serum. Thus, there is a lack of plasma cells in agammaglobulinemia, an increase in pl...

Colorectal cancer affects a large number of people. There is an urgent need to develop novel treatments for this disease. In recent years, research on medical applications atmospheric low temperature plasma (ALTP) has been actively conducted, and treatment one the targets. study, we focused colorectal evaluated as new method. vivo in vitro experiments were conducted using plasma-treated saline ...

Introduction Cold plasma is a self-sterilized, painless, and non-contact method in surgeries. These properties allow it to be applied to the living tissues and heat-sensitive parts. The aim of this study was to design a new cold plasma producer device and evaluate the effects of cold argon plasma on decreasing the coagulation time of blood drop in vitro and that of the injured liver blood in vi...

Abstract The present application wish to seem at the event of validation bio analytical method and pharmacokinetic study selexipag its related impurities in rat plasma using LC–MS/MS. optimized contains gradient elution with a flow rate 1 ml/min X-Bridge phenyl column (150 × 4.6 mm, 3.5 µ). A buffer mL formic acid l liter water acetonitrile mixture is used as mobile phase. 30 min run time was f...

Objective: Phthalates, despite their endocrine disrupting effects, are widely used as plastifiants. Environmental exposure of phthalates was demonstrated to cause fetal death and reproductive toxicity in human beings, well laboratory animals. However, underlying mechanisms not clear.
 Material Methods: Here, we examine the impact di(2-ethylhexyl) phthalate (DEHP) dibutyl (DBP)on rat lungs,...