Background: Memory loss is the main disorder accompanied by Alzheimer's disease (AD). Objectives: We aimed to investigate protective effects of aminoguanidine (Amg) on cell apoptosis in hippocampal CA1 region and memory impairment male rats received scopolamine (Scop). Methods: Thirty Wistar (200 - 250 g) were randomly divided into three groups saline-saline group, Scop + saline, Amg groups. Th...

the aim of the present study was to clarify if old n-mri rat, a strain which is easily available in iran and cheap to maintain, is a suitable alternative to those previously reported. in this model, we compared three quantifiable parameters between old and young rats: biochemically, involving measurement of differences in the lipid profile. histologically, the differences of the thickness of th...

objective(s): intracerebral injection of bone marrow stromal cells (bmscs) is being investigated as a therapeutic tool to prevent alzheimer's disease (ad). our aim was to investigate the effects of bmscs by intrathecal injection in ad rat model. materials and methods: bmscs were obtained from the bone marrow of wistar rat and transplanted into ad rat model via intrathecal injection. the ra...

background: in the present study, the submandibularsalivary gland microscopic morphology of the adult africangiant pouched rat was investigated. this study was carried out toprovide the basic histology of this organ in the giant pouched rat,to accompany the dearth of information of its microscopicarchitecture in the available literature. this becomes of evenhigher importance when considering th...

Alzheimer’s disease (AD) is an age-associated dementia disorder characterized by A? plaques and neurofibrillary tangles. There a strong link between cerebrovascular angiopathy, oxidative stress, inflammation, glucose metabolism abnormalities with the development of AD. In this study, we investigated therapeutic influences artemisinin TSP-1-human endometrial-derived stem cells (TSP-1-hEDSCs) on ...

Recordings from CA1 pyramidal cells were made in rat hippocampal slices (in vitro). Activation of cholinergic receptors associated with tetanization of GABAergic inputs from stratum pyramidale transformed the hyperpolarizing GABA-mediated inhibitory postsynaptic potentials into depolarizing responses of rat hippocampal CA1 pyramidal neurons. The synaptic transformation was characterized by a si...