The von Willebrand disease (vWD) is a hereditary coagulopathy. There is no gender predilection. Clinically characterized by mucocutaneous bleeding, especially nose bleeding, menorrhagia and bleeding after trauma. This article reports a case of a 52-year-old Caucasian male patient with vWD, who presented with extensive bleeding in the tongue after a lacerating injury caused by accidental biting,...

Pavia, IRCCS Policlinico S. Matteo, p.le Golgi 3, 27100 Pavia, Italy. Received March 1, 1995; accepted May 8, 1995. G astrointestinal bleeding is a well-known event in patients suffering from congenital hemostatic disorders. In hereditary hemorrhagic telangiectasia it is the most frequent form of bleeding after epistaxis; in hemophilia the reported incidence varied from 10 to 25%. In contrast, ...

Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS) is a rare autosomal dominant disorder that caused by colony stimulating factor 1 receptor gene mutation degenerating the cerebral white matter. It characterized various symptoms such as progressive cognitive decline, personality changes, and motor disorders. Since these clinical features are not consistent, HDLS often underdiag...

BACKGROUND In patients with hereditary or constitutional chromosomal anomalies, testicular carcinoma can develop sporadically or on the basis of an underlying hereditary genetic defect. Greater knowledge of these genetic defects would provide more insight into the molecular pathways that lead to testicular carcinoma. To the authors' knowledge, little attention has been paid to date to the comor...

Laboratory testing in hemostasis is a subject of growing concern among the specialists. To put it plainly, the standard assays that have been in widespread use for more than 40 years (APTT and PT assays for clotting, aggregometry for platelets) are not sensitive and specific for too many major disorders of hemostasis; their parameters can remain within normal ranges when patient is in acute dan...

Although non-melanoma skin cancers are the most predominant malignancies in the Caucasian population and hemophilia A is one of the most frequent hereditary bleeding disorders, medical literature data about the management of non-melanoma skin cancers in patients with hemophilia are surprisingly scarce. In this case report we describe the treatment of a patient with multiple recurrent non-melano...