BACKGROUND Traditional genetic testing focusses on analysis of one or a few genes according to clinical features; this approach is changing as improved sequencing methods enable simultaneous analysis of several genes. Neonatal diabetes is the presenting feature of many discrete clinical phenotypes defined by different genetic causes. Genetic subtype defines treatment, with improved glycaemic co...

shwaehman syndrome, next to cystic fibrosis, is the second cause of congenita! exocrine pancreatic insufficiency in children. it appears as steatorrhea, recurrent infections and hematologic abnormalities such as neutropenia, skeletal dysplasia and short stature. in this study, we reviewed 3 patients' histories. all of them showed cellular chemotaxic defect. one of them had been affected by neph...

The alpha-2 agonist, medetomidine (MED), and its pure active enantiomer dexmedetomidine (DMED), are used clinically in small animal practice as potent sedatives, analgesic agents, muscle relaxants, and as adjunct agents for balanced anaesthesia. However, their cardiovascular effects limit their use. The use of constant rate infusion (CRI) for administration of MED was studied in order to provid...

The deformation of an initially spherical capsule, freely suspended in simple shear flow, can be computed analytically in the limit of small deformations [D. Barthés-Biesel, J.M. Rallison, The time-dependent deformation of a capsule freely suspended in a linear shear flow, J. Fluid Mech. 113 (1981) 251–267]. Those analytic approximations are used to study the influence of themesh tessellationme...

poisoning remains a major cause of hospital admission into the emergency department and intensive care unit. proper diagnosis is the cornerstone for optimal management of poisoned patients. since the definitive analytical confirmation of the nature of the toxicant involved in the poisoning cannot be rapidly obtained in the majority of healthcare facilities, diagnosis relies on the medical histo...

klinefelter syndrome includes a group of chromosomal disorders with at least one  additional  x  chromosome  in  male  karyotype  (46,xy).  up  to  now, different dental manifestations such as taurodontism, congenital absence of permanent teeth, shovel incisors, occlusal anomalies and increased permanent tooth size have been reported. a case of klinefelter syndrome with very rare dental feature...

An enormous body of evidence supports the activation of caspases may be responsible for the neurodegeneration associated with Alzheimer’s disease (AD) and for that reason, caspases are potential therapeutic targets for the management of this disorder. However, till date, the studies testing with prospective role of caspase inhibitors for the treatment of AD have yet to be realized. Obviously, t...

conclusions adherence to the meddiet, according to mds and sofi-mds, may not predict mets components and mets incidence after 3 years of follow-up in iranian adult populations. results after adjusting for potential confounders, neither higher mds nor higher sofi-mds were significantly associated with the mean values of mets components and the risk of metabolic abnormalities incidence after 3 ye...