background: breast conservation therapy (bct) is the standard of care for early stage breast cancer. the procedure can be a challenge for the surgeon if the lesion is non-palpable. for excision of non-palpable breast lesions, they should be localized precisely before surgery. there are different techniques such as the wgl (wire guided localization), roll (radio-guided occult lesion localization...

Abstract While radioguided surgery (RGS) traditionally relied on detecting gamma rays, direct detection of beta particles could facilitate the tumour margins intraoperatively by reducing radiation noise emanating from distant organs, thereby improving signal-to-noise ratio imaging technique. In addition, most existing detectors do not offer surface sensing or capabilities. Therefore, we explore...

The management of primary hyperparathyroidism is not without controversy. There is controversy as to which imaging technique (if any) should be used to localize a parathyroid adenoma (1,2). There is controversy as to when surgery should be recommended in an asymptomatic patient; although some would argue that all patients are symptomatic but simply do not realize it! There is also controversy a...

1Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy; 2Division of Surgery, John Wayne Cancer Institute, Santa Monica, California; 3Radiotherapy and Nuclear Medicine Department, Regional Hospital of Padua, Padua, Italy; 4Institute of Endocrine Surgery, University of Pisa Medical School, Pisa, Italy; and 5Institute of General Surgery, University of Padua Medical S...