In early mitosis, the END (Emi1/NuMA/Dynein-dynactin) network anchors the anaphase-promoting complex/cyclosome (APC/C) to the mitotic spindle and poles. Spindle anchoring restricts APC/C activity, thereby limiting the destruction of spindle-associated cyclin B and ensuring maintenance of spindle integrity. Emi1 binds directly to hypophosphorylated APC/C, linking the APC/C to the spindle via NuM...

A new approach to predicting the Y-chromosome haplogroup from a set of Y-STR marker values is presented and compared to other approaches. The method has been implemented in an Excel-based program, where an arbitrary number of STR markers may be input and a “goodness of fit” score for 10 haplogroups (E3a, E3b, G, I1a, I1b, I1c, J2, N3, R1a, and R1b) is returned. This method has been applied to 1...

Ghrelin is a 28–amino acid peptide initially isolated from rat and human stomachs as an endogenous ligand for the growth hormone secretagogue receptor type 1a (GHS-R1a) (1) using an intracellular calcium influx assay on a stable cell expressing rat GHS-R. At the time of its discovery in 1999, ghrelin was known to increase growth hormone release from the pituitary gland by binding to GHS-R1a, an...

A new Bayesian allele-frequency approach to predicting the Y-chromosome haplogroup from a set of Y-STR marker values is presented and compared to other approaches. The method has been implemented in an Excel-based program, where an arbitrary number of STR markers may be input and a “goodness of fit” score for 15 haplogroups (C, E3a, E3b, G, H, I1a, I1b1, I1b2, J, L, N, O, Q, R1a, and R1b) and t...