3-(l-Halo-2-oxo-2-substitutedethyl)-2(lH)quinoxalinones, Furo[2,3-b]quinoxalines An efficient method for the synthesis of furo[2,3-b]quinoxalines has been devised. Thus, 3-halo-2-arylfuro[2,3-b]quinoxalines, 5a-5c were synthesized by the action of conc. H2SO4 on 3-(l-halo-2-oxo-2-arylethyl)-2(lH)quinoxalinones, 3b, 3c and 3f respectively. When 3-(1 -halo-2-oxo-2-substitutedethyl)-2(1H)quinoxali...

• HPPD is one of the most promising targets for new herbicides. A family novel inhibitors based on triketone-quinoxaline scaffold was designed and synthesized. One particular product (7d) gave highest inhibition newly synthesized derivatives. Triketone-quinoxaline derivatives provide a useful molecular discovery HPPD-inhibiting </ItemCont...

The title compound, C(28)H(22)N(4), is the unexpected by-product of the reaction of 2-hydroxy-acetophenone and 1,2-diamino-benzene under iodine catalysis, during which a carbon-carbon σ-bond between two quinoxaline units was formed. Although a fully oxidized title compound should sterically be possible, only one quinoxaline ring is fully oxidized while the second ring remains in the reduced for...

The title compound, C(18)H(8)Cl(4)N(4), exists in a cis configuration with respect to the bridging C=C bond. The two essentially planar quinoxaline ring systems [maximum deviations = 0.012 (1) and 0.022 (1) Å] are inclined at an angle of 59.84 (3). In the crystal, adjacent mol-ecules are linked into chains propagating along [001] via inter-molecular C-H⋯N hydrogen bonds. Weak inter-molecular π-...

SR protein-specific kinase-1 (SRPK-1) has been identified as a validated target for hepatitis B virus (HBV). A series of novel tricyclic quinoxaline derivatives was designed and synthesised as potential kinase inhibitory antiviral agents and was found to be active and selective for SRPK-1 kinase. Most of these novel compounds have drug-like properties according to experimentally determined LogP...

In the present study, a novel catalyst was well designed by incorporating the tungstophosphoric acid into the magnetic chitosan, as highly stable composite, in which the iron oxides were used the strong super-magnetic core. The prepared composite was characterized by several methods, including FTIR, XRD, SEM, TEM and EDS and its catalytic activity was examined in a facile, green and highly effi...

An efficient and eco-friendly protocol for the synthesis of quinoxaline derivatives employing a condensation reaction between 1,2-diketone and 1,2-diaminobenzene derivative has been developed. The reaction of  1,2-diketone and 1,2-diaminobenzene derivative was carried out in water at room temperature using 10 mol% of task-specific dicationic ionic liquid as a catalyst. The results show that...