the heterocyclic compounds have a great importance in medicinal chemistry. one of the most important heterocycles in medicinal chemistry are quinazolines possessing wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-hiv, anticancer and analgesic activities. this skeleton is an important pharmacophore considered as a privileged structur...

wide range of quinazolinone biological properties including: antibacterial, anticancer, and anti-inflammatory activities encouraged us to synthesis some fused quinazolinone derivatives. anthranilic acid was condensed with chloro acylchloride followed by dehydration to form the benzoxazinone intermediate; subsequent addition of an amine provided the fused quinazolinones. deoxyvasicinone which wa...

A convenient synthesis for 1,3,4-thiadiazolyl quinazolinone derivatives is described via facile cyclization of anthranilic acid with succinic anhydride and upon reaction glycine afforded 3-glycinyl derivative (2), which then treated thiosemicarbazide produced (3). Also, the key intermediate isothiocyanatobenzoazinone (13) synthesized checked triazolyl-(14), oxooxazolidinyl-(15) triazinanyl-(16a...