quinapril

Acute, subacute, and chronic toxicity studies, carcinogenicity bioassays, and reproductive and genetic toxicology studies were performed with quinapril, an ACE inhibitor used in the treatment of hypertension. Acute toxicity is minimal in rodents, and repeated dosing elicits gastric irritation, juxtaglomerular apparatus (JGA) hypertrophy and hyperplasia and tubular degenerative changes in the ki...

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Hemodynamic effects of quinapril, a novel angiotensin-converting enzyme inhibitor

Journal: :Clinical Pharmacology and Therapeutics 1990

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