Phenolic composition of different extracts of honeydew melon seeds and their antioxidant activity was determined for the first time. Phenolic compounds were identified using a reversed phase high performance liquid chromatography with diode array detection (HPLC-DAD) method. Results showed the identification of five phenolic compounds in water extract namely gallic acid and its derivative, hydroxyb...

Quercetin belongs to the flavonoid family, which is one of most frequent types plant phenolics. This compound a natural substance having number pharmacological effects, including anticancer and antioxidant capabilities, as well being strong inhibitor various toxicologically important enzymes. We discuss potential newly recently synthesized quercetin-based derivatives inhibit SARS-CoV-2 protein....

This study aimed to isolate bacterial neuraminidase (BNA) inhibitory O-methylated quercetin derivatives from the aerial parts of S. pubescens. All isolated compounds were identified as (1–4), which exhibited be noncompetitive inhibitors against BNA, with IC50 ranging 14.0 84.1 μM. The responsible (1–4) showed a significant correlation between BNA effects and number O-methyl groups on quercetin;...

The dried female flowers of Hagenia abyssinica (Bruce) J. F. Gmel. (Rosaceae) are traditionally used as an anthelmintic remedy in Ethiopia and formerly were incorporated into the European Pharmacopoeia. One-, two- and tricyclic phloroglucinol derivatives (kosins) were suggested to be the active principles. However, polar constituents may also contribute to the activity. Therefore, we investigat...

The leaves of Myrcia DC. ex Guill species are used in traditional medicine and are also exploited commercially as herbal drugs for the treatment of diabetes mellitus. The present work aimed to assess the qualitative and quantitative profiles of M. bella hydroalcoholic extract, due to these uses, since the existing legislation in Brazil determines that a standard method must be developed in orde...

1. There is a growing interest in the anti-oxidant characteristics and use of flavonoids in the management of cardiovascular diseases. The cardiovascular mechanism of action of these plant derivatives remains controversial. This study compared the effects of the flavonoid quercetin with those of the anti-oxidant vitamin ascorbic acid (vitamin C) on the reactivity of aortic rings from spontaneou...

Purpose: To determine the influence of 2 wk of quercetin (Q; 1000 mg·d) compared with placebo (P) supplementation on exercise performance and skeletal muscle mitochondrial biogenesis in untrained, young adult males (N = 26, age = 20.2 ± 0.4 yr, V·O2max = 46.3 ± 1.2 mL·kg·min). Methods: Using a randomized, crossover design with a 2-wk washout period, subjects provided blood and muscle biopsy sam...