Recent studies have begun to reveal the genes underlying quantitative trait differences between closely related populations. Not all quantitative trait loci (QTL) are, however, equally likely to be detected. QTL studies involve a limited number of crosses, individuals, and genetic markers and, as a result, often have little power to detect genetic factors of small to moderate effects. In this a...

Circulating microRNAs (miRNAs) are potential biomarkers useful in cancer diagnosis. They have been found to be bound to various carriers like proteins, lipoprotein particles, and exosomes. It is likely that only miRNAs in particular carriers, but not the overall quantity, are directly related to cancer development. Herein, we developed a method for rapid separation of different miRNA carriers i...

Molecular biomarkers are changes measured in biological samples that reflect disease states. Such markers can help clinicians identify types of cancer or stages of progression, and they can guide in tailoring specific therapies. Many efforts to identify biomarkers consider genes that mutate between normal and cancerous tissues or changes in protein or RNA expression levels. Here we define locat...

Interleukin-6 is a biomarker of inflammation which has been suggested as having potential discriminatory ability for myocardial infarction. Because of its high assaying cost it is very expensive to evaluate this marker. In order to reduce this cost we propose pooling the specimens. In this paper we examine the efficiency of ROC curve analysis, specifically the estimation of the area under the R...

Rockefeller Archive Center Research Reports Online is a periodic publication of the Rockefeller Archive Center, a division of The Rockefeller University. Edited by Ken Rose and Erwin Levold under the general direction of the Center's director, Darwin H. Stapleton, Research Reports Online is intended to foster the network of scholarship in the history of philanthropy and to highlight the diverse...

1. Some philosophical problems are decidedly esoteric. It might be thought that certain counterexamples Larry Temkin and Stuart Rachels have offered to the transitivity of the better-than relation are prime instances. For the most compelling of these putative counterexamples rely on our evaluative judgments concerning the quality of hypothetical lives that last an incredibly long time. And if t...

Discrimination of quantity (magnitude) was investigated in zebrafish (Danio rerio). Male zebrafish chose to approach the location previously occupied by the larger in number between 2 groups of female conspecifics (no longer visible at test) in sets of 1 versus 2 items, and 2 versus 3 items, but failed at 3 versus 4 items; similarly, when tested with larger numbers, zebrafish succeeded with 2 v...

High-density lipoprotein (HDL) particles are characterized by their heterogeneity in composition, structure, and biological properties. In addition to the major structural protein apolipoprotein A1, HDL proteomes and lipidomes show great diversity. Such constituents presumably carry out the multitude of HDL functions, for example, reverse cholesterol transport, antioxidant, anti-inflammatory, a...

Suppeshas developedacharacteristicandconceptuallyunifiedapproach to the theoriesof physicalgeometry andphysicalquantity, basedon ideas andformal techniques which he has also helped to develop within the representationaltheory ofmeasurement (RTM). These interrelatedideas, techniques and results are directly relevant to the philosophyof physics,butremainmostlyunknown withinthatcontext. HereIaimto...