We are developing methods to image molecular and cellular events in living subjects. In this study, we validate imaging of protein-protein interactions in living mice by using bioluminescent optical imaging. We use the well studied yeast two-hybrid system adapted for mammalian cells and modify it to be inducible. We employ the NF-kappaB promoter to drive expression of two fusion proteins (VP16-...

in order to evaluate the effects of foliar micronutrients on quantitative and qualitative yield of safflower (carthamus tinctorius l.), a field experiment was carried out at research farm of agricultural faculty, zabol university during growing season of 2005-2006. the experiment performed based on rcbd with 3 replications and 7 treatments including: fe, zn, b, pair combination of them and cont...

an experiment was conducted to optimize consumption of zinc and evaluate of zinc effects on quantitative and qualitative traits of winter wheat under saline soil condition. it was done by three replications in randomized complete block design. the experiment had four treatments as control without zn, 40 kg.ha-1 zn as znso4, 80 kg.ha-1 zn as znso4 in soil and 120 kg.ha-1 zn as znso4 in soil. ele...

UNLABELLED Hub proteins (those engaged in most physical interactions in a protein interaction network (PIN) have recently gained much research interest due to their essential role in mediating cellular processes and their potential therapeutic value. It is straightforward to identify hubs if the underlying PIN is experimentally determined; however, theoretical hub prediction remains a very chal...

Human plasma protein binding (PPB) is an important pharmacokinetic property in drug design. Hologram quantitative structure-activity relationships (HQSAR) were conducted on a series of structurally diverse molecules with known PPB. The best statistical model (q = 0.72, r = 0.91) was used to predict the PPB of 62 test set compounds, and the predicted values were in good agreement with the experi...