Clinicians are well aware that responses to QT-prolonging drugs vary among individuals.1 A drug dose (and concentration) that produces minimal QT prolongation in one patient may, in an apparently indistinguishable subject, produce marked QT prolongation and torsade de pointes. This variability in response to an exogenous stressor is paralleled by variability in the extent to which a given mutat...

We study the transverse-momentum (qT ) and rapidity (y) distributions of the Higgs boson in perturbative QCD, including the most advanced theoretical information presently available: fixed-order perturbation theory at Next-to-Leading Order (NLO) in the large-qT region (qT ∼ MH , being MH the Higgs mass), and soft-gluon resummation at the Next-to-Next-to-Leading Logarithmic accuracy (NNLL) in th...

Long QT syndrome is associated with lethal tachyarrhythmia that can lead to syncope, seizure, and sudden death. Congenital long QT syndrome is a genetic disorder, characterized by delayed cardiac repolarization and prolongation of the QT interval on the electrocardiogram (ECG). Type 2 congenital long QT is linked to mutations in the human ether a go-go-related gene (HERG). There are environment...

We propose a simplified version of the Qt framework, called as Qt Operational Model, which is integrated into the Efficient SMT-based Context-Bounded Model Checking tool, for verifying actual Qt-based applications. Experimental results show that our proposed approach can be effectively and efficiently applied to verify Qt-based real-world applications from consumer electronics.

introduction: prolongation of qt interval might result in dangerous cardiac arrhythmias, including torsades de pointes (tdp), consequently leading to syncope or death. a limited number of studies carried out in this respect to date have shown that qt interval might increase during pregnancy. on the other hand, it has been shown that each pregnancy might result in an increase in the risk of card...

BACKGROUND Automatic measurement becomes a preference, and indeed a necessity, when analyzing 1000 s of ECGs in the setting of either drug-inducing QT prolongation screening or genome-wide association studies of QT interval. The problem is that individual manufacturers apply different computerized algorithms to measure QT interval. We conducted a comparative study to assess the outcomes with di...

OBJECTIVES The purpose of this study was to evaluate the efficacy of various antiarrhythmic drugs at prolonging the QT interval into the normal range and preventing ventricular arrhythmias in patients with short QT syndrome. BACKGROUND Short QT syndrome is a recently described genetic disease characterized by short QT interval, high risk of sudden death, atrial fibrillation, and short refract...

AIMS Repolarization has rate-dependent and rate-independent components. A function considering such components separately was validated in canine Purkinje fibres and applied to the QT/RR relation in humans. METHODS AND RESULTS Action potential duration (APD) was measured in Purkinje fibres during steady-state pacing at different cycle lengths (CL) and after prolonged quiescence (APD(0)). The ...

Several QT correction (QTc) formulas have been used for assessing the QT liability of drugs. However, they are known to under- and over-correct the QT interval and tend to be specific to species and experimental conditions. The purpose of this study was to determine a suitable formula for halothane-anesthetized dogs highly sensitive to drug-induced QT interval prolongation. Twenty dogs were ane...

BACKGROUND Universal QT correction formulae have been shown to under or overcorrect the QT interval duration. Individual QT-R-R modeling has been proposed as a preferable solution for heart rate correction of QT intervals. However, the QT-R-R relationship stability over time needs to be evaluated. METHODS The present report is part of randomized, double-dummy, and placebo-controlled 4-way cro...