نتایج جستجو برای: q31

تعداد نتایج: 182  

Journal: :Molecular and cellular biology 1996
G M Dolganov R S Maser A Novikov L Tosto S Chong D A Bressan J H Petrini

In this report, we describe the identification and molecular characterization of a human RAD50 homolog, hRAD50. hRAD50 was included in a collection of cDNAs which were isolated by a direct cDNA selection strategy focused on the chromosomal interval spanning 5q23 to 5q31. Alterations of the 5q23-q31 interval are frequently observed in myelodysplasia and myeloid leukemia. This strategy was thus u...

Journal: :Molecular human reproduction 2010
V Loup I Bernicot P Janssens B Hedon S Hamamah F Pellestor T Anahory

Complex chromosome rearrangements (CCRs) are structural aberrations involving three or more breakpoints on two or more chromosomes. These CCRs result in a high rate of chromosome imbalances potentially leading to subfertility and congenital abnormality. In this study, we analysed meiotic segregation in the sperm of a patient with a familial CCR 46, XY,t(1;19;13)(p31;q13.2;q31)mat included in an...

Journal: :Journal of virology 1984
M Rabin O C Uhlenbeck D M Steffensen W F Mangel

Simian virus 40 DNA sequences, integrated on human chromosome 7 in two transformed human-mouse hybrid somatic cell lines, were mapped to a specific chromosomal locus by in situ hybridization. To detect the integrated viral DNA by in situ hybridization, we increased the sensitivity of the technique by using as a probe 125I-labeled simian virus 40 cRNA (2 X 10(9) to 3 X 10(9) dpm/micrograms) prep...

Journal: :American journal of cancer research 2012
Eiji Takaoka Hiroshi Sonobe Kunihiro Akimaru Shuji Sakamoto Taro Shuin Masanori Daibata Takahiro Taguchi Akira Tominaga

A molecular cytogenetic analysis was performed on HS-RMS-2, a cell line established in this laboratory from a rare pleomorphic type of rhabdomyosarcoma. G-banding and multicolor-FISH analyses revealed that the cells have a complex chromosomal composition. Comparative genomic in situ hybridization (CGH) detected eight highly amplified regions at 1p36.1-p36.2, 1p31-p32, 1q21-q31, 8q12-q21, 8q24-q...

Journal: :Cancer research 2005
Muy-Teck Teh Diana Blaydon Tracy Chaplin Nicola J Foot Spyros Skoulakis Manoj Raghavan Catherine A Harwood Charlotte M Proby Michael P Philpott Bryan D Young David P Kelsell

Basal cell carcinoma is the most common human cancer with increasing incidence reported worldwide. Despite the aberrant signaling role of the Hedgehog pathway, little is known about the genetic mechanisms underlying basal cell carcinomas. Towards a better understanding of global genetic events, we have employed the Affymetrix Mapping 10K single nucleotide polymorphism (SNP) microarray technique...

Journal: :European journal of cancer 2006
Maija Tarkkanen Marcelo L Larramendy Tom Böhling Massimo Serra Claudia M Hattinger Aarne Kivioja Inkeri Elomaa Piero Picci Sakari Knuutila

Malignant fibrous histiocytoma (MFH) of bone is a rare, highly malignant tumour. As very little is known about its genetic alterations, 26 bone MFHs were analysed by comparative genomic hybridisation (CGH). Twenty-three tumours (89%) had DNA sequence copy number changes (mean, 7.2 changes per sample). Gains were more frequent than losses (gains:losses=2.5:1). Minimal common regions for the most...

2015
Manavi Dang Smeeta Gajendra Shalini Goel Bhawna Jha Tushar Sahni Ritesh Sachdev

5. Park TS, Song J, Kim JS, et al. 8p11 myeloproliferative syndrome preceded by t(8;9)(p11;q33), CEP110/FGFR1 fusion transcript: morphologic, molecular, and cytogenetic characterization of myeloid neoplasms associated with eosinophilia and FGFR1 abnormality. Cancer Genet Cytogenet 2008;181:93-9. 6. Kim M, Lim J, Lee A, et al. A case of chronic myelomonocytic leukemia with severe eosinophilia ha...

Journal: :Genes, chromosomes & cancer 2001
M D Odero K Carlson M J Calasanz I Lahortiga V Chinwalla J D Rowley

TEL/ETV6 is the first transcription factor identified that is specifically required for hematopoiesis within the bone marrow. This gene has been found to have multiple fusion partners; 35 different chromosome bands have been involved in ETV6 translocations, of which 13 have been cloned. To identify additional ETV6 partner genes and to characterize the chromosomal abnormalities more fully, we st...

2008
Katrin Friedrich Theresa Weber Jens Scheithauer Wolfdietrich Meyer Gunter Haroske Klaus Dietmar Kunze Gustavo Baretton

The purpose of this study was to compare the chromosomal genotype between breast cancers with and without secondary manifestations and between primary tumors and their secondary manifestations. Eighty six breast cancers, twenty lymph node metastases, ten distant metastases and ten local recurrences were analyzed by comparative genomic hybridization. Tumors with local recurrences showed signific...

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