نتایج جستجو برای: pyrrole

تعداد نتایج: 3583  

Journal: :Chemical communications 2010
Hiroshi Tanaka Yoshikazu Tanaka Masafumi Minoshima Sho Yamaguchi Shinichiro Fuse Takayuki Doi Susumu Kawauchi Hiroshi Sugiyama Takashi Takahashi

The synthesis of a bicyclic enediyne capable of photosensitive triggering and conjugated to a pyrrole-imidazole polyamide is described. Using UV irradiation, this hybrid molecule is shown to exhibit 100-fold stronger potency for DNA cleavage, in an in vitro assay, as compared to the enediyne without the DNA-localizing pyrrole-imidazole.

Journal: :Chemical Record 2021

The cover picture shows a DNA recognition system that imitates the dimer formation of natural transcription factor pairs. Pyrrole-imidazole polyamides bind to programmable sequences and enable us target specific genomic regions. We have developed artificial factors by expanding function pyrrole-imidazole with other compounds (e.g., peptides epigenetic modulators), achieving gene regulation chem...

Faramarz Rostami-Charati Mehdi Shahraki Mohammad R Hosseini- Tabatabaei Zinatossadat Hossaini

one-pot synthesis of pyrrole derivatives via reaction between activated carbonyl compounds, primary amines and 1,3-dicarbonyls under solvent-free conditions is described‎.

Journal: :Molecules 2015
M Angeles García M Angeles Farrán Dolores Santa María Rosa M Claramunt M Carmen Torralba M Rosario Torres Carlos Jaime José Elguero

The association constants of the complexes formed by two hosts containing pyrrole, amide and azine (pyridine and 1,8-naphthyridine) groups and six guests, all monoanions (Cl-, CH3CO2-, NO3-, H2PO4-, BF4-, PF6-), have been determined using NMR titrations. The X-ray crystal structure of the host N2,N5-bis(6-methylpyridin-2-yl)-3,4-diphenyl-1H-pyrrole- 2,5-dicarboxamide (1) has been solved (P21/c ...

Journal: :Organic & biomolecular chemistry 2012
K C Gowri Sreedevi Ajesh P Thomas S Ramakrishnan P S Salini M G Derry Holaday M L P Reddy A Srinivasan

Synthesis, spectral and structural characterization of a pyrroloindolizine derivative having structural similarity with calix[2]pyrrole is described. Here, two pyrrole rings are connected with two meso-carbon atoms having an N,α-linkage and an α,β-linkage to afford the smallest analogue in the calixpyrrole family. Detailed NMR spectroscopic studies along with single crystal X-ray analysis confi...

2011
Yan-Hong He Gang-Qiang Wang Zhi Guan

The ionic liquid 1-butyl-3-methyl-imidazolium hydrogen sulfate, [bmim]HSO4, was used as a catalyst and reaction medium for the pyrrole synthesis, and a wide range of aliphatic, aromatic, heteroaromatic and carboxylic 1,4-diketones easily underwent condensations with aniline and ethylenediamine to form polysubstituted pyrroles. Sequential decarboxylation/Paal-Knorr pyrrole condensation was obser...

Journal: :Clinical chemistry 1986
K Tomokuni Y Hirai

We investigated the formation of delta-aminolevulinic acid (ALA)-pyrrole and subsequent color development used in determining ALA in urine. Of three condensation reagents examined--acetylacetone, ethyl acetoacetate, and methyl acetoacetate--the last was the best. When the ALA-pyrrole is reacted with Ehrlich's reagent in ethyl acetate according to one procedure, the optimum concentration of perc...

2010
Wei-Na Wu Lei Yang Xiao-Xia Li Bao-Feng Qin Qiu-Fen Wang

In the title compound, C(16)H(18)N(2)O(2), the mol-ecule adopts an E conformation about the C=N double bond. The dihedral angle between the pyrrole and phenyl rings is 41.55 (8)°. In the crystal structure, pairs of inter-molecular N-H⋯O hydrogen bonds link the mol-ecules into centrosymmetric dimers. In the dimer, the two pyrrole rings are almost coplanar and the two phenyl rings are parallel to...

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