In the title compound, C(29)H(27)ClN(4)O(2), the six-membered ring of the pyridazine group is nearly planar [maximum deviation = -0.062 (2) Å] and its mean plane makes dihedral angles of 43.05 (9), 44.71 (10) and 72.57 (9)°, respectively, with the two phenyl and benzene rings. The piperazine ring has a chair conformation and its mean plane is almost perpendicular to the attached benzene ring, w...

In the title compound, C(9)H(9)ClN(4), the dihedral angle between the aromatic rings is 6.25 (9)°. The whole mol-ecule is approximately planar (r.m.s. deviation = 0.070 Å). In the crystal, π-π inter-actions between the centroids of the pyridazine rings [separation = 3.5904 (10) Å] occur.

The nine-membered fused-ring system of the title pyridazine derivative, C(7)H(7)N(3)OS, is almost planar (r.m.s. deviation 0.012 Å). In the crystal, the amino H atom forms a hydrogen bond to the ketonic O atom of a neighboring mol-ecule to generate a centrosymmetric dimer.

The nonsteroidal anti-inflammatory agent (+ or -)-suprofen [alpha-methyl-4-(2-thienylcarbonyl)benzeneacetic acid] was evaluated as a P450 2C9 inactivator. (+ or -)-Suprofen inactivated the diclofenac-4-hydroxylase activity of baculovirus-expressed P450 2C9 in a time- and concentration-dependent manner, which was consistent with mechanism-based inactivation. The loss of activity followed pseudo-...

A new family of bridged cyclometallating ligands is reported, which incorporate two terdentate N(∧)C(∧)N-coordinating binding sites linked via pyrazine, pyrimidine or pyridazine units. Dinuclear Ir(III) complexes of one ligand have been prepared and crystallographically characterised; they display intense red phosphorescence.

The reaction of 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid phenylamide with tertiary butyl carbazate and subsequent condensation of the resulting carbamate derivative with a chalcone provided a facile new approach to pyrrolo[1,2-b]pyridazine derivatives.

Microwave-enhanced, highly efficient protocols for the synthesis of synthetically and biologically important 2,3,6-trisubstituted pyridazine architectures have been developed by sequential amination/Suzuki coupling/alkylation reactions. This powerful strategy is an economical and highly chemoselective protocol for the synthesis of diversified pyridazines. The total synthesis of gabazine (SR-955...