The blue-green phenazine, Pyocyanin (PYO), is a well-known virulence factor produced by Pseudomonas aeruginosa, notably during cystic fibrosis lung infections. It is toxic to both eukaryotic and bacterial cells and several mechanisms, including the induction of oxidative stress, have been postulated. However, the mechanism of PYO toxicity under the physiological conditions of oxygen limitation ...

Salicylic acid (SA) is a phenolic metabolite produced by plants and is known to play an important role in several physiological processes, such as the induction of plant defense responses against pathogen attack. Here, using the Arabidopsis thaliana-Pseudomonas aeruginosa pathosystem, we provide evidence that SA acts directly on the pathogen, down regulating fitness and virulence factor product...

Of 72 clinical isolates of Pseudomonas aeruginosa examined for simultaneous production of secondary metabolites, 86% produced 2-alkyl-4-hydroxyquinolines, 75% produced rhamnolipids, and 58% produced phenazines, including pyocyanin. Whereas isolates producing two or one constituted smaller groups, 39% released all three metabolites. Metabolite production did not appear to influence site of infec...

The influence of outward extracellular electron transfer (EET) Pseudomonas aeruginosa in accelerating corrosion 304 stainless steel was investigated. With less NO3? available as acceptor, P. biofilm accelerated the pitting corrosion. ICP-MS and XPS results indicated that promoted bioreductive dissolution iron oxides passive film steel. Using situ scanning electrochemical microscopy, we establis...

Bacteria control gene expression by quorum sensing (QS) mechanism owing to producing small signal molecules associated with population density. Both gram-positive and gram-negative bacteria use QS manage various physiological characteristics, including bioluminescence, virulence expression, biofilm formation, antibiotic resistance. Impatience balsamina is a flowering, perennial annual herb indi...

Pseudomonas aeruginosa is an important pathogen that frequently associated with nosocomial infections. The goal of this work was to determine the relationship between quorum sensing system (QS) and production virulence factors in P. aeruginosa. A number 100 isolates were collected from various clinical sources different Mansoura university hospitals period April 2018 till 2019. PCR screening QS...