The photoswitchable-PROTACs have photoswitches that work as an actual ON/OFF switch for any particular bioactivity. In reported studies, the activity correlates with photostationary state and quantum yield of a specific isomer under definite wavelength light, providing spatiotemporal control over protein degradation (an example photochemistry-based precision medicine). studies role azobenzenes ...

In this research, we have developed the data driven computational walking model to overcome the problem with traditional kinematics based model. Our model is adaptable and can adjust the parameter morphological similar to human. The human walk is a combination of different discrete sub-phases with their continuous dynamics. Any system which exhibits the discrete switching logic and continuous d...

explore the earliest levels of striate cortical processing: the first stage, where orientation sensitivity emerges, and the second stage, where stimulus selectivity is further refined. The approach is wholecell recording from cat in vivo. Neurons in the lateral geniculate nucleus of the thalamus have circular receptive fields whose subregions, center and surround are concentrically arranged and...

explore the earliest levels of striate cortical processing: the first stage, where orientation sensitivity emerges, and the second stage, where stimulus selectivity is further refined. The approach is wholecell recording from cat in vivo. Neurons in the lateral geniculate nucleus of the thalamus have circular receptive fields whose subregions, center and surround are concentrically arranged and...

explore the earliest levels of striate cortical processing: the first stage, where orientation sensitivity emerges, and the second stage, where stimulus selectivity is further refined. The approach is wholecell recording from cat in vivo. Neurons in the lateral geniculate nucleus of the thalamus have circular receptive fields whose subregions, center and surround are concentrically arranged and...

introduction: the aim of this in vitro study was to evaluate the effect of mta-based sealer (mta fillapex), eugenol-based sealer (dorifill) and an epoxy resin sealer (ah plus) on the bond strength of fiber posts cemented with a self-etch adhesive. materials and methods: the root canals of 72 maxillary incisors were prepared using the step-back technique after removing/cutting off the crowns. th...

Simple cells in the visual cortex respond to the precise position of oriented contours (Hubel and Wiesel, 1962). This sensitivity reflects the structure of the simple receptive field, which exhibits two sorts of antagonism between on and off inputs. First, simple receptive fields are divided into adjacent on and off subregions; second, within each subregion, stimuli of the reverse contrast evok...

explore the earliest levels of striate cortical processing: the first stage, where orientation sensitivity emerges, and the second stage, where stimulus selectivity is further refined. The approach is wholecell recording from cat in vivo. Neurons in the lateral geniculate nucleus of the thalamus have circular receptive fields whose subregions, center and surround are concentrically arranged and...

A silicon Mach–Zehnder modulator with a low-loss phase shifter formed by restricted-depth doping is fabricated and characterized. The phase shifter has a PN junction at the bottom of the rib waveguide, whereas the top of the rib is un-doped. Device simulations confirm that the phase-shifter loss is reduced by 26−28% with an increased phase-shifter length to keep a π phase shift with the same bi...

For any knot T transverse to a given contact structure on a 3-manifold, we exhibit a Legendrian two-component link L = L1 t L2 such that T equals the transverse push-off of L1 and contact (+1)surgery on L has the same effect as a Lutz twist along T .