To test the accuracy of creatinine as a marker for estimating urinary volume and its use as a nutritional index, the possible interference of forage intake and forage quality over creatinine excretion was evaluated. For this, sheep were fed different levels of pearl millet (Pennisetum americanum (L) Leeke) or Italian ryegrass (Lolium multiflorum Lam). The experiment consisted of a compilation o...

Haloalkyl purines i.e. 2,6-diamino-8-(chloromethyl) purine 10; 2, 6-diamino-X- (chloromethyl) purine 17; 2,6-diamino-8-(chloropropylp) urine 18; were synthesized by two distinct but facile methods. The N-alkylating potential of 2, 6-diamino-8- (chloromethyl) purine was investigated. The following products 2,6-diamino-8-(Nbenzyl- N-methyl) purine 11; 2,6-diamino-8-(4-nitro anilinomethyl) pur...

Purine derivatives like adenosine 5′-triphosphate (ATP) is the powerhouse of cell and essential to maintain cellular homeostasis activity. Besides this they also act as a chemical messenger when released into extracellular milieu because stress insult. The ATP (eATP) well its metabolite triggers purinergic signaling affecting various processes such cytokine chemokine production, immune function...

Inhibitory effect of 8-alkyl cyclic AMP derivatives on the soluble guanylate cyclase activity from human platelets was investigated. Cyclic AMP derivatives with alkyl chains of 6 or less carbons at 8-position of the purine base were not inhibitory, but the derivatives with alkyl chains of 7 or more carbons produced significant inhibition of the soluble guanylate cyclase activity. The extent of ...

On the basis of our study on the structure-activity relationships of 1,3,7-alkylxanthines and condensed-purines on cAMP-phosphodiesterase 4 (PDE 4) isoenzyme inhibitor, we investigated the synthesis and the inhibitory activity of 3-phenylxanthine and 4-phenyl[i]condensed-purine derivatives. Xanthines and condensed-purines with the phenyl group exhibited potent and selective PDE 4 inhibitory act...

Although purinergic compounds are widely involved in the intra- and intercellular communication of the nervous system, little is known of their involvement in the growth and regeneration of neuronal connections. In dissociated cultures, the addition of adenosine or guanosine in the low micromolar range induced goldfish retinal ganglion cells to extend lengthy neurites and express the growth-ass...

Pyrazofurin (NSC 143095) as the monophosphate derivative is a potent inhibitor of orotidine 5'-monophosphate (OMP) decarboxylase of the pyrimidine pathway and has been proposed to inhibit 5-aminoimidazole-4-carboxamide ribotide (AICAR) transformylase (EC 2.1.2.3) of the purine pathway (J. F. Worzalla, and M. J. Sweeney, Pyrazofurin inhibition of purine biosynthesis via 5-aminoimidazole-4-carbox...

Recent work has shown that certain growth inhibitory purine analogues undergo anabolism to ribonucleoside 5’-phosphates (1, 2). Ribonucleoside 5’-phosphate derivatives of purine analogues that effect temporary remission of some human leukemias have been synthesized (3-6), and effects of these nucleotides on enzymatic interconversions of naturally occurring purine nucleotides have been studied (...