This study evaluated whether music-induced aesthetic "chill" responses, which typically correspond to peak emotional experiences, can be objectively monitored by degree of pupillary dilation. Participants listened to self-chosen songs versus control songs chosen by other participants. The experiment included an active condition where participants made key presses to indicate when experiencing c...

PURPOSE To evaluate the feasibility of screening for retinopathy of prematurity (ROP) by assessing the pupillary response to mydriatics. METHODS This observational case series included 134 eyes of 67 premature infants with birth weight less than 2,000 grams and gestational age less than 33 weeks. A composite eye drop composed of phenylephrine 1%, tetracaine and tropicamide 0.5% was applied 3 ...

PURPOSE This study aimed to quantify the pupillary light reaction during high altitude exposure using the state of the art Compact Integrated Pupillograph (CIP) and to investigate a potential correlation of altered pupil reaction with severity of acute mountain sickness (AMS). This work is related to the Tübingen High Altitude Ophthalmology (THAO) study. METHODS Parameters of pupil dynamics (...

The recent discovery of melanopsin-containing retinal ganglion cells (mRGCs) has led to a fundamental reassessment of non-image forming processing, such as circadian photoentrainment and the pupillary light reflex. In the conventional view of retinal physiology, rods and cones were assumed to be the only photoreceptors in the eye and were, therefore, considered responsible for non-image process...

It has long been known that pupils-the apertures that allow light into the eyes-dilate and constrict not only in response to changes in ambient light but also in response to emotional changes and arousing stimuli (e.g., Fontana, 1765). Charles Darwin (1872) related changes in pupil diameter to fear and other "emotions" in animals. For decades, pupillometry has been used to study cognitive proce...

Purpose To develop an animal behavioral assay for the quantitative assessment of the functional efficacy of optogenetic therapies. Methods A triple-knockout (TKO) mouse line, Gnat1-/-Cnga3-/-Opn4-/-, and a double-knockout mouse line, Gnat1-/-Cnga3-/-, were employed. The expression of channelrhodopsin-2 (ChR2) and its three more light-sensitive mutants, ChR2-L132C, ChR2-L132C/T159C, and ChR2-1...

In an attempt to determine the presence or absence of correlation between the intraocular pressure-increasing and pupil-dilating effects of corticosteroids, the effect of topically applied dexamethasone and various autonomic agents has been studied in 12 hospitalised, healthy, young adult volunteers. Dexamethasone caused an average increase of intraocular pressure of 8-8 mmHg and of pupillary d...

During embryonic development the lens receives nourishment from the posterior and anterior tunica vasculosa lentis. During the fourth month of gestation, macrophages play a role in the regression of the tunica vasculosa lentis, revealing the pupillary aperture posteriorly. The persistent pupillary membrane (PPM) represents a congenital remnant of the anterior tunica vasculosa lentis. As in this...

The activation of processing resources has widespread effects in the nervous system. A model of pupillary control systems (Steinhauer S.R. , Hakerem G., 1992. The pupillary response in cognitive psychophysiology and schizophrenia. Ann. N.Y. Acad. Sci. 658, 182-204) had predicted that ongoing cognitive activation should result in inhibition of the light reaction at the level of the oculomotor nu...

Spontaneous pupillary behaviour in darkness provides information about a subject's level of vigilance. To establish infrared video pupillography (IVP) as a reliable and objective test in the detection and quantification of daytime sleepiness, the definition of numerical parameters is an important precondition characterising spontaneous pupil behaviour adequately for further statistical procedur...