Platelet adhesion in the annular perfusion system developed by Baumgartner was studied under pulsatile, oscillatory, or steady flow conditions. To investigate in what way pulsatile flow affects platelet adhesion, we developed a flow system that produces a sinusoidal laminar flow superimposed on a constant component in the annular perfusion chamber. Frequencies and amplitudes of this sinusoidal ...

HSR Proceedings in Intensive Care and Cardiovascular Anesthesia 2011, Vol. 4 Corresponding author: Giulio Melisurgo Cardiovascular and Thoracic Department Università Vita-Salute San Raffaele Via Olgettina, 60 20132 Milan, Italy e-mail: [email protected] Continuous-flow ventricular assist devices (VADs) are the standard of care for implantable mechanical circulatory support (1). However, s...

CFD modelling is a powerful, but largely under-utilised tool for biomedical applications. In particular, it has great potential for helping us better understand the mechanisms responsible for cardiovascular disease such as artherosclerosis and thrombi formation. Flow behaviour in blood vessels has been shown to depend strongly on features of the local geometry such as branching, bending, and re...

An in-vitro flow study was conducted in a mildly atherosclerotic main coronary artery casting of man using sugar-water solutions simulating blood viscosity. Steady flow results indicated substantial increases in pressure drop, and thus flow resistance at the same Reynolds number, above those for Poiseuille flow by 30 to 100 percent in the physiological Reynolds number range from about 100 to 40...

In this paper, we study optimal in vitro realization of pulsatile coronary artery flows using newly proposed closed-loop feedback algorithms with a clearly defined mathematical performance objective, and we compare several flow control device technologies in terms of their ability to generate pulsatile flow signals as accurately as possible. In the literature, there are several published result...

Tortuous aneurysmal arteries are often associated with a higher risk of rupture but the mechanism remains unclear. The goal of this study was to analyze the buckling and post-buckling behaviors of aneurysmal arteries under pulsatile flow. To accomplish this goal, we analyzed the buckling behavior of model carotid and abdominal aorta with aneurysms by utilizing fluid-structure interaction (FSI) ...

In this research, we present a new designed experimental setup for study of characteristics of pulsatile flow in elastic tubes, aiming to simulate arterial blood flow. This system includes four major components: (1) a pulsatile pump producing original arterial flow, (2) an elastic element to simulate coupling of the heart with the arterial system, (3) an elastic tube with mechanical characteris...