BACKGROUND Flattening filter-free (FFF) linear accelerators (linacs) are capable of delivering dose rates more than 4-times higher than conventional linacs during SBRT treatments, causing some to speculate whether the higher dose rate leads to increased toxicity owing to radiobiological dose rate effects. Despite wide clinical use of this emerging technology, clinical toxicity data for FFF SBRT...

Amiodarone (A) is a widely-used antiarrhythmic drug. Pulmonary toxicity is the most serious adverse effect with an estimated mortality of 1 to 33 percent. In order to determine an element helpful for diagnosis, we examined four patients with amiodarone-induced pulmonary toxicity, three patients treated with A, without evidence of pulmonary toxicity but with a main underlying pulmonary disease, ...

The articles highlighted in this issue are “Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days after Intratracheal Instillation” by Chiu-Wing Lam, John T. James, Richard McCluskey, and Robert L. Hunter (pp. 126–134) and “Comparative Pulmonary Toxicity Assessment of Single-Wall Carbon Nanotubes in Rats” by D. B. Warheit, B. R. Laurence, K. L. Reed, D. H. Roach, G. A. M. Rey...

INTRODUCTION Few cases of pulmonary toxicity related to epidermal growth factor receptor-targeted agents have been described. CASE PRESENTATION We report a case of a 63-year-old white male with stage IV non-small cell lung cancer treated with erlotinib who developed a interstitial lung disease. CONCLUSION Respiratory symptoms during treatment with erlotinib should alert clinicians to rule o...

Methotrexate (MTX) is the most widely used drug in cancer chemotherapy and considered to be first-line for treatment of a number rheumatic non-rheumatic disorders. The pulmonary toxicity, hepatotoxicity MTX are two its major side effects. Other toxicities such as endocrinological GI cutaneous hematological fatal malfunction or loss, malignancy can also occur, but at significantly lower rate pre...